Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CXCR1 | P25024 | 5/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217181 | 0.85 | ALDH1A1 (0.48) | LMNAPOLBHDAC2L3MBTL1HPGD | |
| SCHEMBL20217243 | 0.82 | KDM4E (0.51) | LMNAHPGDALDH1A1 | |
| SCHEMBL20217320 | 0.78 | KCNK3 (0.44) | KCNK3 | |
| SCHEMBL20217176 | 0.77 | ROCK2 (0.50) | LMNAL3MBTL1MAPTCYP3A4CYP2D6 | |
| SCHEMBL20217342 | 0.76 | APLNR (0.49) | — | |
| SCHEMBL20217347 | 0.73 | ALDH1A1 (0.47) | LMNAALDH1A1 | |
| SCHEMBL20217138 | 0.73 | ROCK1 (0.52) | — | |
| SCHEMBL25516265 | 0.73 | MAPT (0.43) | LMNAPOLBL3MBTL1HPGDALDH1A1 | |
| SCHEMBL20217203 | 0.72 | TAS1R3 (0.59) | — | |
| SCHEMBL20217174 | 0.72 | GRN (0.43) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |