Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | APP | P05067 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1532464 | 0.79 | KDM4E (0.64) | KDM4EALDH1A1MAPTTRPA1KMT2A | |
| SCHEMBL21457136 | 0.75 | MAPT (0.70) | KDM4EALDH1A1MAPTTRPA1KMT2A | |
| SCHEMBL7598649 | 0.73 | ALDH1A1 (0.61) | KDM4EALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL5139573 | 0.70 | ALDH1A1 (0.42) | ALDH1A1KMT2ALMNAHTTMEN1 | |
| SCHEMBL8458208 | 0.70 | TRPA1 (0.62) | KDM4EALDH1A1MAPTTRPA1KMT2A | |
| SCHEMBL10041814 | 0.70 | LMNA (0.44) | ALDH1A1MAPTKMT2ALMNAHTT | |
| SCHEMBL9881101 | 0.70 | ALDH1A1 (0.42) | KDM4EALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL12866087 | 0.69 | EGFR (0.68) | KDM4EALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL3368866 | 0.68 | TRPA1 (0.60) | KDM4EALDH1A1MAPTTRPA1KMT2A | |
| SCHEMBL3369090 | 0.68 | TRPA1 (0.60) | KDM4EALDH1A1MAPTTRPA1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11834663-B2 | Fibrotic treatment | MONASH UNIVERSITY (AU) | 2023-12-05 | — | — | US | disclosed |
| US-20180223287-A1 | FIBROTIC TREATMENT | MONASH UNIVERSITY (AU) | 2018-08-09 | — | — | US | disclosed |
| US-20180170891-A1 | 4H-Pyran Compounds as Insulin-Regulated Aminopeptidase (IRAP) Inhibitors | MONASH UNIVERSITY (AU) | 2018-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180223287-A1 | FIBROTIC TREATMENT | ENPEP, IL4I1, LNPEP | KDM4E 1261/4885ALDH1A1 1064/4885MAPT 4232/4885 |
| US-20180170891-A1 | 4H-Pyran Compounds as Insulin-Regulated Aminopeptidase (IRAP) Inhibitors | IAPP, ENPEP, DNPEP | KDM4E 1470/4885ALDH1A1 2853/4885MAPT 113/4885 |
| US-11834663-B2 | Fibrotic treatment | MMP1, ENPEP, RNPEP | KDM4E 1936/4885ALDH1A1 1883/4885MAPT 3950/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.