Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | SCARB1 | Q8WTV0 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | F2R | P25116 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.38 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28922224 | 0.85 | MAPT (0.56) | MAPTPOLBATMSIGMAR1MEN1 | |
| SCHEMBL30014239 | 0.85 | MAPT (0.56) | MAPTPOLBATMSIGMAR1MEN1 | |
| SCHEMBL30013278 | 0.78 | SIGMAR1 (0.47) | MAPTSIGMAR1MEN1KMT2ALMNA | |
| SCHEMBL20486333 | 0.78 | SIGMAR1 (0.47) | MAPTSIGMAR1MEN1KMT2ALMNA | |
| SCHEMBL3039635 | 0.77 | MAPT (0.59) | MAPTPOLBATMSIGMAR1MEN1 | |
| SCHEMBL30013273 | 0.76 | MAPT (0.66) | MAPTPOLBATMSIGMAR1MEN1 | |
| SCHEMBL12608627 | 0.76 | MAPT (0.56) | MAPTPOLBATMSIGMAR1MEN1 | |
| SCHEMBL12608625 | 0.76 | MAPT (0.56) | MAPTPOLBATMSIGMAR1MEN1 | |
| SCHEMBL12608628 | 0.75 | SIGMAR1 (0.60) | MAPTPOLBATMSIGMAR1MEN1 | |
| SCHEMBL11413547 | 0.74 | MAPT (0.75) | MAPTPOLBATMSIGMAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110573240-B | Selectively permeable graphene oxide membranes | 日东电工株式会社 | 2022-11-22 | — | — | CN | disclosed |
| EP-3589390-B1 | SELECTIVELY PERMEABLE GRAPHENE OXIDE MEMBRANE | NITTO DENKO CORP (JP) | 2022-08-17 | — | — | EP | disclosed |
| US-20200261861-A1 | SELECTIVELY PERMEABLE GRAPHENE OXIDE MEMBRANE | NITTO DENKO CORPORATION (JP) | 2020-08-20 | — | — | US | disclosed |
| CN-110573240-A | selectively permeable graphene oxide membranes | 日东电工株式会社 | 2019-12-13 | — | — | CN | disclosed |
| WO-2018160871-A2 | SELECTIVELY PERMEABLE GRAPHENE OXIDE MEMBRANE | NITTO DENKO CORPORATION (JP) | 2018-09-07 | — | — | WO | disclosed |