Tetramethylrhodamine

Tetramethylrhodamine

SCHEMBL2054818

CN(C)c1ccc2c(-c3ccccc3C(=O)O)c3ccc(=[N+](C)C)cc-3oc2c1

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.71
THRB P10828 2/20 0.71
RECQL P46063 2/20 0.71
BLM P54132 2/20 0.71
KMT2A Q03164 2/20 0.71
TDP1 Q9NUW8 2/20 0.71
P2RY6 Q15077 1/20 0.58
CA12 O43570 3/20 0.52
CA1 P00915 3/20 0.52
CA2 P00918 3/20 0.52
CA9 Q16790 3/20 0.52
CA14 Q9ULX7 1/20 0.48
GBA1 P04062 2/20 0.46
FTO Q9C0B1 2/20 0.45
ABCB1 P08183 2/20 0.45
ITPR1 Q14643 1/20 0.45
USP2 O75604 4/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
APAF1 O14727 1/20 0.43
RAB9A P51151 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tetramethylrhodamine SCHEMBL29838750 0.91 P2RY6 (0.67) MEN1THRBRECQLBLMKMT2A
SCHEMBL14399201 0.91 MEN1 (0.67) MEN1THRBRECQLBLMKMT2A
Tetramethylrhodamine SCHEMBL13815486 0.91 P2RY6 (0.67) MEN1THRBRECQLBLMKMT2A
Tetramethylrhodamine SCHEMBL30091907 0.90 P2RY6 (0.66) MEN1THRBRECQLBLMKMT2A
Tetramethylrhodamine SCHEMBL29587824 0.90 P2RY6 (0.66) MEN1THRBRECQLBLMKMT2A
SCHEMBL14399388 0.89 MEN1 (0.64) MEN1THRBRECQLBLMKMT2A
Rhodamine Ii SCHEMBL12310066 0.89 MEN1 (0.64) MEN1THRBRECQLBLMKMT2A
Rhodamine Ii SCHEMBL30320900 0.89 MEN1 (0.64) MEN1THRBRECQLBLMKMT2A
SCHEMBL10293759 0.89 P2RY6 (0.64) MEN1THRBRECQLBLMKMT2A
SCHEMBL12307301 0.89 MEN1 (0.64) MEN1THRBRECQLBLMKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 155 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230321226-A1 SYNTHETIC ARCHAEAL DIETHER LIPIDS APHP (ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS) (FR) 2023-10-12 US disclosed
US-20230295222-A1 Conjugation Reagents and Methods Using 1,2-Cyclohexanediones Encodia, Inc. (US) 2023-09-21 US disclosed
US-20230287217-A1 Zwitterionic Cell-Permeant and Water-Soluble Rhodamine Dyes for Quantitative Imaging Applications OREGON HEALTH & SCIENCE UNIVERSITY 2023-09-14 US disclosed
EP-4220163-A2 NEW COLORS FOR CHROMOGENIC IHC AND ISH STAINING WITH MULTI-DYE QUINONE METHIDE AND TYRAMIDE CONJUGATES Ventana Medical Systems, Inc. (US) 2023-08-02 EP disclosed
US-11639366-B2 Conjugation reagents and methods using 1,2-cyclohexanediones Encodia, Inc. (US) 2023-05-02 US disclosed
WO-2022133552-A1 FLUORESCENT DYES Exopharm Limited (AU) 2022-06-30 WO disclosed
EP-2603231-B1 Compositions comprising a pH-sensitive membrane insertion polipeptide. RHODE ISLAND BOARD OF GOVERNORS FOR HIGHER EDUCATION (US) 2021-12-29 EP disclosed
US-10752833-B2 Optical element for correcting color blindness NITTO DENKO CORPORATION (JP) 2020-08-25 US disclosed
EP-3043811-B1 COMPOSITIONS AND METHODS FOR THE DELIVERY OF MOLECULES INTO LIVE CELLS TEXAS A & M UNIV SYS (US) 2020-03-25 EP disclosed
US-20190194535-A1 OPTICAL ELEMENT FOR CORRECTING COLOR BLINDNESS NITTO DENKO CORPORATION (JP) 2019-06-27 US disclosed
US-20070184513-A1 Substrates for beta-lactamase and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-08-09 US disclosed
US-20070161026-A1 REGENTS LABELED WITH ENERGY TRANSFER DYES APPLERA CORPORATION (US) 2007-07-12 US disclosed
US-20070161027-A1 OLIGONUCLEOTIDES AND ANALOGS LABELED WITH ENERGY TRANSFER DYES APPLERA CORPORATION (US) 2007-07-12 US disclosed
US-20070154927-A1 ENERGY TRANSFER DYES WITH ENHANCED FLUORESCENCE APPLERA CORPORATION (US) 2007-07-05 US disclosed
US-20070154925-A1 METHODS OF ANALYZING POLYNUCLEOTIDES EMPLOYING ENERGY TRANSFER DYES APPLERA CORPORATION (US) 2007-07-05 US disclosed
US-20070154926-A1 Linkers for donor dyes to acceptor dyes for energy transfer between dyes with fluorescence APPLERA CORPORATION (US) 2007-07-05 US disclosed
US-20070154924-A1 OLIGONUCLEOTIDES AND ANALOGS LABELED WITH ENERGY TRANSFER DYES APPLERA CORPORATION (US) 2007-07-05 US disclosed
US-20070087400-A1 Covalent tethering of functional groups to proteins and substrates therefor PROMEGA CORPORATION 2007-04-19 US disclosed
US-7169939-B2 Energy transfer dyes with enhanced fluorescence APPLERA CORPORATION (US) 2007-01-30 US disclosed
US-7157575-B2 Substrates for β-lactamase and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-01-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230321226-A1 SYNTHETIC ARCHAEAL DIETHER LIPIDS DDOST, ABHD16A, GMDS MEN1 2422/4885THRB 4359/4885RECQL 695/4885
US-20070154924-A1 OLIGONUCLEOTIDES AND ANALOGS LABELED WITH ENERGY TRANSFER DYES RBM28, TRDMT1, RPS28 MEN1 3292/4885THRB 1607/4885RECQL 481/4885
US-20070087400-A1 Covalent tethering of functional groups to proteins and substrates therefor WASF2, NOTUM, YIPF5 MEN1 3107/4885THRB 4156/4885RECQL 2314/4885
US-20230295222-A1 Conjugation Reagents and Methods Using 1,2-Cyclohexanediones TNNI3, CHD1, TNNT2 MEN1 2915/4885THRB 1569/4885RECQL 483/4885
US-11639366-B2 Conjugation reagents and methods using 1,2-cyclohexanediones TNNI3, CHD1, TNNT2 MEN1 2915/4885THRB 1569/4885RECQL 483/4885
US-20070161027-A1 OLIGONUCLEOTIDES AND ANALOGS LABELED WITH ENERGY TRANSFER DYES RBM28, TRDMT1, RTCB MEN1 3323/4885THRB 1641/4885RECQL 503/4885
US-20070154926-A1 Linkers for donor dyes to acceptor dyes for energy transfer between dyes with fluorescence SLC25A21, RPS28, ZCCHC8 MEN1 3434/4885THRB 3447/4885RECQL 1140/4885
US-20070161026-A1 REGENTS LABELED WITH ENERGY TRANSFER DYES SOAT1, GFPT1, CBR3 MEN1 2922/4885THRB 2626/4885RECQL 856/4885
US-20070154925-A1 METHODS OF ANALYZING POLYNUCLEOTIDES EMPLOYING ENERGY TRANSFER DYES POLRMT, NOP2, NSUN3 MEN1 4042/4885THRB 2379/4885RECQL 373/4885
US-20230287217-A1 Zwitterionic Cell-Permeant and Water-Soluble Rhodamine Dyes for Quantitative Imaging Applications SLC1A5, SLCO1B1, SLCO2B1 MEN1 3011/4885THRB 3479/4885RECQL 2548/4885
US-20070154927-A1 ENERGY TRANSFER DYES WITH ENHANCED FLUORESCENCE SLC25A21, ZCCHC8, SLC25A1 MEN1 2922/4885THRB 2907/4885RECQL 1432/4885
US-20070184513-A1 Substrates for beta-lactamase and uses thereof CMBL, DBH, NCEH1 MEN1 3743/4885THRB 1172/4885RECQL 974/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.