SCHEMBL20636767

SCHEMBL20636767

C[Si](C)(C)c1ccc(Nc2ccc(F)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KCNH3 Q9ULD8 5/20 0.43
MAPT P10636 2/20 0.41
ALDH1A1 P00352 1/20 0.41
MAPK10 P53779 1/20 0.41
MEN1 O00255 2/20 0.40
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
KMT2A Q03164 2/20 0.40
TXN P10599 1/20 0.40
LMNA P02545 1/20 0.40
ALOX12 P18054 1/20 0.40
MAPK1 P28482 1/20 0.40
TDP1 Q9NUW8 1/20 0.39
HTR2C P28335 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
AURKA O14965 1/20 0.39
GAA P10253 1/20 0.39
POLB P06746 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2270398 0.88 ALDH1A1 (0.43) MAPTALDH1A1MEN1NPC1RAB9A
SCHEMBL8932050 0.85 NR1H2 (0.46) NPC1RAB9ASMN1; SMN2
SCHEMBL395770 0.80 ALDH1A1 (0.50) KCNH3MAPTALDH1A1MAPK10MEN1
SCHEMBL762138 0.79 ALDH1A1 (0.62) MAPTALDH1A1MEN1RAB9AKMT2A
SCHEMBL916183 0.79 HPGD (0.56) MAPTALDH1A1MEN1NPC1RAB9A
SCHEMBL916027 0.74 NFKB1 (0.52) MAPTALDH1A1MEN1NPC1RAB9A
SCHEMBL915383 0.74 MAPT (0.71) KCNH3MAPTALDH1A1MEN1NPC1
SCHEMBL916557 0.74 L3MBTL1 (0.47) MAPTALDH1A1MEN1NPC1RAB9A
SCHEMBL917356 0.74 RAB9A (0.49) MAPTALDH1A1MEN1NPC1RAB9A
SCHEMBL915691 0.74 NR1H2 (0.44) MAPTMEN1NPC1RAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11306060-B2 Compound and organic electronic element comprising same LG CHEM, LTD. (KR) 2022-04-19 US disclosed
CN-109071449-B Compound and organic electronic element comprising same 株式会社LG化学 2022-04-15 CN disclosed
CN-110049964-B Novel compound and organic light emitting device using the same 株式会社LG化学 2022-03-22 CN disclosed
EP-3428152-B1 COMPOUND AND ORGANIC ELECTRONIC ELEMENT COMPRISING SAME LG CHEMICAL LTD (KR) 2021-11-03 EP disclosed
US-20190152919-A1 COMPOUND AND ORGANIC ELECTRONIC ELEMENT COMPRISING SAME LG CHEM, LTD. (KR) 2019-05-23 US disclosed
US-20190152919-A1 COMPOUND AND ORGANIC ELECTRONIC ELEMENT COMPRISING SAME LG CHEM, LTD. (KR) 2019-05-23 US disclosed
EP-3428152-A1 COMPOUND AND ORGANIC ELECTRONIC ELEMENT COMPRISING SAME LG Chem, Ltd. (KR) 2019-01-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190152919-A1 COMPOUND AND ORGANIC ELECTRONIC ELEMENT COMPRISING SAME OR10J3, ETV6, ESR1 KCNH3 694/4885MAPT 1486/4885ALDH1A1 1103/4885
US-11306060-B2 Compound and organic electronic element comprising same OR10J3, ETV6, BMI1 KCNH3 459/4885MAPT 1633/4885ALDH1A1 1193/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.