SCHEMBL20670946

SCHEMBL20670946

C[C@]1(CO)O[C@@H](n2cnc3c(N)nc(F)nc32)C[C@@H]1O

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHCY P23526 5/20 0.54
LMNA P02545 2/20 0.52
NT5E P21589 2/20 0.52
HIF1A Q16665 1/20 0.52
ADORA3 P0DMS8 3/20 0.46
ADORA2A P29274 2/20 0.46
ADORA2B P29275 1/20 0.46
ADORA1 P30542 1/20 0.46
PNP P00491 1/20 0.45
TP53 P04637 1/20 0.45
HTT P42858 1/20 0.45
PDE4D Q08499 1/20 0.45
PDE3A Q14432 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
RXFP1 Q9HBX9 1/20 0.45
CA5A P35218 1/20 0.43
HSP90AA1 P07900 1/20 0.40
HSP90B1 P14625 1/20 0.40
CHKA P35790 1/20 0.40
DNMT1 P26358 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21614181 1.00 AHCY (0.54) AHCYLMNANT5EHIF1AADORA3
SCHEMBL31652941 1.00 AHCY (0.54) AHCYLMNANT5EHIF1AADORA3
SCHEMBL30689530 1.00 AHCY (0.54) AHCYLMNANT5EHIF1AADORA3
SCHEMBL24195283 1.00 AHCY (0.54) AHCYLMNANT5EHIF1AADORA3
SCHEMBL9548611 0.89 AHCY (0.53) AHCYLMNANT5EADORA3ADORA2A
SCHEMBL9548618 0.89 AHCY (0.53) AHCYLMNANT5EADORA3ADORA2A
SCHEMBL25396825 0.88 AHCY (0.55) AHCYLMNANT5EHIF1AADORA3
SCHEMBL25865564 0.88 AHCY (0.56) AHCYLMNANT5EHIF1AADORA3
SCHEMBL23966231 0.87 PDE4D (0.61) LMNANT5EADORA3ADORA2AADORA2B
SCHEMBL12736902 0.87 PDE4D (0.61) LMNANT5EADORA3ADORA2AADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250215039-A1 NUCLEOSIDES FOR TREATING CANCER PRIMEFOUR THERAPEUTICS INC (US) 2025-07-03 US disclosed
US-12037623-B2 Enzymatic synthesis of 4′-ethynyl nucleoside analogs Merck, Sharp & Dohme LLC (US) 2024-07-16 US disclosed
US-20230374486-A1 ENGINEERED PHOSPHOPENTOMUTASE VARIANT ENZYMES INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT 2023-11-23 US disclosed
US-11795445-B2 Engineered phosphopentomutase variant enzymes CODEXIS, INC. (US) 2023-10-24 US disclosed
US-11793827-B2 Adenosine derivative and pharmaceutical composition comprising the same BRII BIOSCIENCES, INC. (US) 2023-10-24 US disclosed
WO-2023192499-A1 NUCLEOSIDES FOR TREATING CANCER PRIMEFOUR THERAPEUTICS, INC. (US) 2023-10-05 WO disclosed
US-20230293526-A1 METHOD FOR TREATING CANCER WITH A REVERSE TRANSCRIPTASE INHIBITOR PRIMEFOUR THERAPEUTICS, INC. 2023-09-21 US disclosed
WO-2023178128-A1 METHODS OF TREATING MEDICAL CONDITIONS USING ISLATRAVIR OR A RELATED COMPOUND ROME THERAPEUTICS, INC. (US) 2023-09-21 WO disclosed
US-20230174534-A1 COMPOUNDS USEFUL IN HIV THERAPY GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2023-06-08 US disclosed
US-20230151049-A1 Compounds Useful in HIV Therapy VIIV HEALTHCARE COMPANY (US) 2023-05-18 US disclosed
US-11034948-B2 Engineered phosphopentomutase variant enzymes CODEXIS, INC. (US) 2021-06-15 US disclosed
US-20210154221-A1 4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS AND PREPARATIONS THEREOF MERCK SHARP & DOHME CORP. (US) 2021-05-27 US disclosed
US-10953029-B2 4′-Substituted nucleoside reverse transcriptase inhibitors and preparations thereof MERCK SHARP & DOHME CORP. (US) 2021-03-23 US disclosed
US-20210060051-A1 COMBINED MODALITIES FOR NUCLEOSIDES AND/OR NADPH OXIDASE (NOX) INHIBITORS AS MYELOID-SPECIFIC ANTIVIRAL AGENTS EMORY UNIVERSITY 2021-03-04 US disclosed
WO-2021030306-A1 DRUG DELIVERY SYSTEM FOR THE DELIVERY OF ANTIVIRAL AGENTS MERCK SHARP & DOHME CORP. (US) 2021-02-18 WO disclosed
WO-2021021717-A1 ADENOSINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME BRII BIOSCIENCES, INC. (US) 2021-02-04 WO disclosed
WO-2021003129-A2 ENGINEERED ACETATE KINASE VARIANT ENZYMES CODEXIS, INC. (US) 2021-01-07 WO disclosed
WO-2020263660-A1 PROCESS FOR THE PREPARATION OF 2-FLUOROADENINE MERCK SHARP & DOHME CORP. (US) 2020-12-30 WO disclosed
WO-2020044257-A1 COMPOUNDS USEFUL IN HIV THERAPY GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2020-03-05 WO disclosed
US-20190022115-A1 4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS AND PREPARATIONS THEREOF MERCK SHARP & DOHME CORP. (US) 2019-01-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210154221-A1 4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS AND PREPARATIONS THEREOF HPRT1, SAMHD1, DUT AHCY 519/4885LMNA 2288/4885NT5E 89/4885
US-12037623-B2 Enzymatic synthesis of 4′-ethynyl nucleoside analogs GALE, ENGASE, RNGTT AHCY 499/4885LMNA 2519/4885NT5E 75/4885
US-20230174534-A1 COMPOUNDS USEFUL IN HIV THERAPY CCR5, CD4, LSS AHCY 1161/4885LMNA 2608/4885NT5E 1408/4885
US-11793827-B2 Adenosine derivative and pharmaceutical composition comprising the same ADAR, ADA, ADORA2A AHCY 159/4885LMNA 2057/4885NT5E 58/4885
US-20210060051-A1 COMBINED MODALITIES FOR NUCLEOSIDES AND/OR NADPH OXIDASE (NOX) INHIBITORS AS MYELOID-SPECIFIC ANTIVIRAL AGENTS NOX1, NOX3, NOX4 AHCY 459/4885LMNA 4207/4885NT5E 141/4885
US-20230293526-A1 METHOD FOR TREATING CANCER WITH A REVERSE TRANSCRIPTASE INHIBITOR TYMP, TYMS, DCTD AHCY 248/4885LMNA 3687/4885NT5E 159/4885
US-20250215039-A1 NUCLEOSIDES FOR TREATING CANCER UNG, OGG1, NTPCR AHCY 201/4885LMNA 1053/4885NT5E 83/4885
US-20230151049-A1 Compounds Useful in HIV Therapy CCR5, CD4, NPC1 AHCY 1195/4885LMNA 2405/4885NT5E 1724/4885
US-20190022115-A1 4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS AND PREPARATIONS THEREOF HPRT1, DUT, SAMHD1 AHCY 604/4885LMNA 2165/4885NT5E 122/4885
US-10953029-B2 4′-Substituted nucleoside reverse transcriptase inhibitors and preparations thereof DUT, HPRT1, SAMHD1 AHCY 626/4885LMNA 2109/4885NT5E 115/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.