Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.43 |
| ▸ | GRK2 | P25098 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.41 |
| ▸ | LSS | P48449 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20828420 | 0.80 | DGAT1 (0.47) | ROCK2DGAT1 | |
| SCHEMBL20828341 | 0.79 | DGAT1 (0.48) | ROCK2DGAT1 | |
| SCHEMBL20828481 | 0.79 | FFAR1 (0.45) | BRAFRAF1MAPK14ROCK2GRK2 | |
| SCHEMBL20828418 | 0.78 | DGAT1 (0.44) | ROCK2DGAT1 | |
| SCHEMBL20820817 | 0.78 | DGAT1 (0.50) | ROCK2MCHR1DGAT1TRPV1LRRK2 | |
| SCHEMBL20828451 | 0.78 | BRAF (0.44) | BRAFRAF1MAPK14ROCK2GRK2 | |
| SCHEMBL20828421 | 0.77 | SCD (0.43) | ROCK2DGAT1 | |
| SCHEMBL20828417 | 0.76 | ROCK2 (0.46) | MAPK14ROCK2DGAT1 | |
| SCHEMBL20828342 | 0.74 | DGAT1 (0.58) | MCHR1DGAT1TRPV1 | |
| SCHEMBL22623121 | 0.69 | L3MBTL1 (0.38) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019054430-A1 | AMIDE COMPOUND HAVING AROMATIC HETEROCYCLE | 第一三共株式会社 | 2019-03-21 | — | — | WO | disclosed |