Diniprofylline

Diniprofylline

SCHEMBL2108045

Cn1c(=O)c2c(ncn2CC(COC(=O)c2cccnc2)OC(=O)c2cccnc2)n(C)c1=O

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 0.55
GAA P10253 3/20 0.51
SMN1; SMN2 Q16637 3/20 0.48
RXFP1 Q9HBX9 4/20 0.48
POLB P06746 1/20 0.47
ALDH1A1 P00352 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
ADORA2B P29275 3/20 0.46
MAPK1 P28482 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Diniprofylline SCHEMBL30035984 1.00 LMNA (0.55) LMNAGAASMN1; SMN2RXFP1POLB
SCHEMBL10970100 0.89 LMNA (0.64) LMNAGAASMN1; SMN2RXFP1POLB
SCHEMBL11389921 0.85 LMNA (0.57) LMNAGAASMN1; SMN2RXFP1ALDH1A1
Etofylline Nicotinate SCHEMBL1649975 0.84 ADORA2B (0.64) LMNAGAASMN1; SMN2RXFP1ALDH1A1
SCHEMBL10970102 0.82 LMNA (0.56) LMNAGAASMN1; SMN2RXFP1POLB
SCHEMBL25295543 0.79 LMNA (0.56) LMNAGAASMN1; SMN2RXFP1ADORA2B
SCHEMBL30563571 0.79 LMNA (0.56) LMNAGAASMN1; SMN2RXFP1ADORA2B
SCHEMBL11389732 0.77 PDE1A (0.55) LMNAGAASMN1; SMN2RXFP1ALDH1A1
Etofylline SCHEMBL27405019 0.77 LMNA (0.70) LMNAGAASMN1; SMN2RXFP1POLB
SCHEMBL11377360 0.76 LMNA (0.59) LMNAGAASMN1; SMN2RXFP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
CN-1771022-A Cosmetic composition containing a fatty acid glyceride, an alcohol and a silicone emulsifier OREAL (FR) 2006-05-10 CN claimed
US-12472186-B2 Pharmaceutical compositions and methods of treating cardiovascular diseases Cardix Therapeutics LLC (US) 2025-11-18 US disclosed
US-20250345308-A1 COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING CONDITIONS ANSELLA THERAPEUTICS INC (US) 2025-11-13 US disclosed
US-12201607-B2 Compositions and methods for preventing and treating conditions Ansella Therapeutics, Inc. (US) 2025-01-21 US disclosed
US-20240285639-A1 DEUTERATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES Cardix Therapeutics LLC (US) 2024-08-29 US disclosed
US-20240207279-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES Cardix Therapeutics LLC (US) 2024-06-27 US disclosed
US-11951107-B2 Deuterated pharmaceutical compositions and methods of treating cardiovascular diseases CARDIX Therapeutics, LLC (US) 2024-04-09 US disclosed
US-6680047-B2 FOR USE IN ULTRASOUND IMAGING, CONTRAST AGENTS AMERSHAM HEALTH AS (NO) 2004-01-20 US disclosed
US-20020102215-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2002-08-01 US disclosed
US-20020102217-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2002-08-01 US disclosed
US-6331289-B1 ULTRASOUND CONTRAST AGENTS, SUSPENSION IN AQUEOUS CARRIER LIQUID OF A REPORTER COMPRISING GAS-CONTAINING OR GAS-GENERATING MATERIAL, AGENT CAPABLE OF FORMING AT LEAST TWO TYPES OF BINDING PAIRS WITH TARGET; REPORTER BEING CONJUGATED NYCOMED IMAGING AS (NO) 2001-12-18 US disclosed
US-6264917-B1 MIXTURE OF GAS FILLED MICROBUBBLES AND RELEASING AGENT NYCOMED IMAGING AS (NO) 2001-07-24 US disclosed
US-6261537-B1 TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES NYCOMED IMAGING AS (NO) 2001-07-17 US disclosed
EP-0390612-A1 Drug production using non-cross reactive antibodies SYNBIOTICS CORPORATION (US) 1990-10-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11951107-B2 Deuterated pharmaceutical compositions and methods of treating cardiovascular diseases ADRB2, ADRA2C, ADRB1 LMNA 1687/4885GAA 1649/4885SMN1; SMN2 2580/4885
US-20240285639-A1 DEUTERATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES ADRB2, ADRA2C, ADRB1 LMNA 1687/4885GAA 1649/4885SMN1; SMN2 2580/4885
US-12201607-B2 Compositions and methods for preventing and treating conditions LIPA, COL2A1, COL1A1 LMNA 43/4885GAA 49/4885SMN1; SMN2 93/4885
US-20250345308-A1 COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING CONDITIONS LIPA, COL2A1, COL1A1 LMNA 43/4885GAA 49/4885SMN1; SMN2 93/4885
US-20020102215-A1 Diagnostic/therapeutic agents BID, FUS, FABP1 LMNA 1552/4885GAA 2444/4885SMN1; SMN2 1978/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.