SCHEMBL2108247

SCHEMBL2108247

COc1ccc(C(OC(C(C)=O)[C@H]2O[C@@H](n3ccc(N)nc3=O)[C@H](OCOCCC#N)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.31

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
ST6GAL1 P15907 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15841537 0.99 ST6GAL1 (0.31) ST6GAL1
SCHEMBL2218923 0.94
SCHEMBL2107080 0.87 ST6GAL1 (0.36) ST6GAL1
SCHEMBL15841376 0.86 ST6GAL1 (0.35) ST6GAL1
SCHEMBL2108084 0.86 HPGD (0.38)
SCHEMBL2109084 0.85 TRDMT1 (0.36)
SCHEMBL6574062 0.85
SCHEMBL15879332 0.84 TRDMT1 (0.36)
SCHEMBL4760169 0.83 ST6GAL1 (0.36) ST6GAL1
SCHEMBL2107681 0.81 HPGD (0.37)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1995253-B1 METHOD FOR DETACHING PROTECTING GROUP ON NUCLEIC ACID NIPPON SHINYAKU CO LTD (JP) 2016-12-21 EP disclosed
US-20120322993-A1 Phosphorylation Reagent NIPPON SHINYAKU CO., LTD. (JP) 2012-12-20 US disclosed
EP-1795536-B1 PHOSPHORAMIDITE COMPOUND AND METHOD FOR PRODUCING OLIGO-RNA NIPPON SHINYAKU CO LTD (JP) 2012-05-02 EP disclosed
US-8158775-B2 Method for detaching protecting group on nucleic acid NIPPON SHINYAKU CO., LTD. (JP) 2012-04-17 US disclosed
US-20090312534-A1 METHOD FOR REMOVAL OF NUCLEIC ACID-PROTECTING GROUP NIPPON SHINYAKU CO., LTD. (JP) 2009-12-17 US disclosed
US-20090149645-A1 METHOD FOR DETACHING PROTECTING GROUP ON NUCLEIC ACID NIPPON SHINYAKU CO., LTD. (JP) 2009-06-11 US disclosed
US-20090137790-A1 METHOD OF CAPPING OLIGONUCLEIC ACID NIPPON SHINYAKU CO., LTD. (JP) 2009-05-28 US disclosed
EP-2017282-A1 METHOD OF CAPPING OLIGONUCLEIC ACID Nippon Shinyaku Co., Ltd. (JP) 2009-01-21 EP disclosed
EP-1995252-A1 METHOD FOR REMOVAL OF NUCLEIC ACID-PROTECTING GROUP Nippon Shinyaku Co., Ltd. (JP) 2008-11-26 EP disclosed
EP-1995253-A1 METHOD FOR DETACHING PROTECTING GROUP ON NUCLEIC ACID Nippon Shinyaku Co., Ltd. (JP) 2008-11-26 EP disclosed
US-20070282097-A1 Phosphoramidite Compound And Method For Producing Oligo-Rna NIPPON SHINYAKU CO., LTD. (JP) 2007-12-06 US disclosed
EP-1795536-A1 PHOSPHORAMIDITE COMPOUND AND METHOD FOR PRODUCING OLIGO-RNA Nippon Shinyaku Co., Ltd. (JP) 2007-06-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090312534-A1 METHOD FOR REMOVAL OF NUCLEIC ACID-PROTECTING GROUP NSUN2, RNASEH1, RNASE1 ST6GAL1 516/4885
US-20090137790-A1 METHOD OF CAPPING OLIGONUCLEIC ACID RNGTT, DUT, ADAR ST6GAL1 3218/4885
US-20070282097-A1 Phosphoramidite Compound And Method For Producing Oligo-Rna NSUN2, NSUN3, XRN2 ST6GAL1 1832/4885
US-20120322993-A1 Phosphorylation Reagent CSNK2A2, CSNK2A1, CSNK2B ST6GAL1 793/4885
US-20090149645-A1 METHOD FOR DETACHING PROTECTING GROUP ON NUCLEIC ACID DNASE1, DNASE1L3, NSUN2 ST6GAL1 765/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.