Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25215843 | 0.81 | LMNA (0.60) | GRM4KDM4EKMT2APTGS2MAPT | |
| SCHEMBL10472252 | 0.80 | GRM4 (0.44) | GRM4GAAKDM4ETDP1KMT2A | |
| SCHEMBL30761577 | 0.75 | CNR1 (0.58) | GAAKDM4ETDP1KMT2APTGS2 | |
| SCHEMBL10029258 | 0.74 | ALDH1A1 (0.60) | GRM4GAAKDM4EKMT2AMAPT | |
| SCHEMBL403316 | 0.74 | ALDH1A1 (0.60) | GRM4GAAKDM4EKMT2AMAPT | |
| SCHEMBL4508472 | 0.73 | CES2 (0.64) | GRM4GAAKDM4ETDP1KMT2A | |
| SCHEMBL1147702 | 0.73 | KDM4E (0.73) | KDM4ETDP1MAPTTLR7L3MBTL1 | |
| 2-Picolinic Acid SCHEMBL994022 | 0.72 | L3MBTL1 (0.67) | GRM4GAAKDM4ETDP1KMT2A | |
| SCHEMBL2884583 | 0.72 | PTGS2 (0.50) | GAAKDM4ETDP1KMT2APTGS2 | |
| SCHEMBL25411521 | 0.72 | L3MBTL1 (0.60) | GAAKDM4ETDP1KMT2APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11001555-B2 | Difluoroketamide derivatives as HTRA1 inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2021-05-11 | — | — | US | disclosed |
| US-20190185427-A1 | DIFLUOROKETAMIDE DERIVATIVES AS HTRA1 INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11001555-B2 | Difluoroketamide derivatives as HTRA1 inhibitors | HTRA1, HTR1A, HTR1F | GRM4 2223/4885GAA 1969/4885KDM4E 2060/4885 |
| US-20190185427-A1 | DIFLUOROKETAMIDE DERIVATIVES AS HTRA1 INHIBITORS | HTRA1, HTR1A, HTR1F | GRM4 2223/4885GAA 1969/4885KDM4E 2060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.