SCHEMBL21151877

SCHEMBL21151877

CC(C)(C)OC(=O)CCS(=O)(=O)N1CCC2(CC1)NC(=O)N(Cc1ccccc1)C2=O

nearest known ligand 0.48

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.48
TACR1 P25103 2/20 0.47
LMNA P02545 2/20 0.41
NPC1 O15118 1/20 0.41
HTT P42858 1/20 0.41
RAB9A P51151 1/20 0.41
L3MBTL1 Q9Y468 2/20 0.40
MEN1 O00255 1/20 0.39
ALDH1A1 P00352 4/20 0.38
SMN1; SMN2 Q16637 4/20 0.38
MAPK1 P28482 1/20 0.38
KDM4E B2RXH2 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21151112 0.86 KMT2A (0.56) KMT2ATACR1LMNANPC1HTT
SCHEMBL21150772 0.84 ITGB3 (0.38) TACR1LMNANPC1RAB9A
SCHEMBL24974777 0.80 KMT2A (0.47) KMT2ATACR1LMNANPC1HTT
SCHEMBL3245801 0.79 KMT2A (0.56) KMT2ATACR1LMNANPC1HTT
SCHEMBL9965983 0.71 KMT2A (0.71) KMT2ALMNANPC1HTTRAB9A
SCHEMBL21764913 0.71 GPR119 (0.52) LMNANPC1HTTRAB9A
SCHEMBL4834401 0.69 LMNA (0.48) KMT2ATACR1LMNANPC1HTT
SCHEMBL21150801 0.69 L3MBTL1 (0.54) KMT2ALMNANPC1HTTRAB9A
SCHEMBL23288913 0.69 OPRD1 (0.46) KMT2ATACR1LMNAALDH1A1SMN1; SMN2
SCHEMBL3392659 0.69 LMNA (0.50) KMT2ALMNANPC1HTTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11572370-B2 CD16A binding agents and uses thereof BIOHAVEN THERAPEUTICS LTD. (US) 2023-02-07 US disclosed
WO-2019136442-A1 CD16A BINDING AGENTS AND USES THEREOF KLEO PHARMACEUTICALS, INC. (US) 2019-07-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11572370-B2 CD16A binding agents and uses thereof FCGR1A, FCGR2A, FCGR3B KMT2A 499/4885TACR1 76/4885LMNA 2855/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.