Sugi Predict

Sugi Predict / Compounds / SCHEMBL2115556

SCHEMBL2115556

SCHEMBL2115556

O=C(O)c1cc(Cl)ccc1OC(F)(F)F

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 2/20 0.53
▸ GAA P10253 2/20 0.53
▸ ALDH1A1 P00352 2/20 0.52
▸ TP53 P04637 1/20 0.52
▸ CA1 P00915 1/20 0.50
▸ CA2 P00918 1/20 0.50
▸ DHODH Q02127 1/20 0.48
▸ CASP1 P29466 1/20 0.47
▸ SMN1; SMN2 Q16637 1/20 0.47
▸ POLB P06746 1/20 0.47
▸ HPGD P15428 1/20 0.47
▸ L3MBTL1 Q9Y468 1/20 0.47
▸ ALPL P05186 1/20 0.46
▸ MPO P05164 1/20 0.46
▸ MYC P01106 1/20 0.45
▸ NR4A1 P22736 1/20 0.45
▸ ANO1 Q5XXA6 2/20 0.44
▸ AKR1C2 P52895 1/20 0.44
▸ AKR1C1 Q04828 1/20 0.44
▸ PNLIP P16233 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29646503 1.00 TSHR (0.53) TSHRGAAALDH1A1TP53CA1
SCHEMBL1972984 0.87 AKR1C2 (0.53) TSHRGAADHODHALPLANO1
SCHEMBL24405532 0.87 GAA (0.50) TSHRGAAALDH1A1TP53CA1
SCHEMBL22979516 0.86 TSHR (0.52) TSHRGAAALDH1A1TP53CA1
SCHEMBL31743138 0.85 MAP2 (0.50) GAAALDH1A1ALPLANO1PNLIP
SCHEMBL3922656 0.84 ANO1 (0.42) TSHRGAAALPLANO1PNLIP
SCHEMBL4046170 0.84 DCLRE1B (0.50) DHODHANO1AKR1C2AKR1C1KMO
SCHEMBL30843111 0.82 ABL1 (0.51) ALDH1A1ALPLANO1PNLIPCNR2
SCHEMBL11060112 0.82 POLB (0.52) POLBALPLNR4A1ANO1PNLIP
SCHEMBL27699137 0.82 ALDH1A1 (0.59) TSHRGAAALDH1A1TP53CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12492166-B2 Sulfonylurea derivative and medical uses thereof SHANGHAI SENHUI MEDICINE CO., LTD (CN) 2025-12-09 — — US disclosed
US-20240018103-A1 3-HYDROXYOXINDOLE DERIVATIVES AS CRHR2 ANTAGONIST RAQUALIA PHARMA INC. (JP) 2024-01-18 — — US disclosed
US-20240018103-A1 3-HYDROXYOXINDOLE DERIVATIVES AS CRHR2 ANTAGONIST RAQUALIA PHARMA INC. (JP) 2024-01-18 — — US disclosed
US-20230348371-A1 SULFONYLUREA DERIVATIVE AND MEDICAL USES THEREOF JIANGSU HENGRUI PHARMACEUTICALS CO., LTD. (CN) 2023-11-02 — — US disclosed
US-20230348371-A1 SULFONYLUREA DERIVATIVE AND MEDICAL USES THEREOF JIANGSU HENGRUI PHARMACEUTICALS CO., LTD. (CN) 2023-11-02 — — US disclosed
US-20230348371-A1 SULFONYLUREA DERIVATIVE AND MEDICAL USES THEREOF JIANGSU HENGRUI PHARMACEUTICALS CO., LTD. (CN) 2023-11-02 — — US disclosed
US-11802120-B2 Fused cyclic urea derivatives as CRHR2 antagonist RAQUALIA PHARMA INC. (JP) 2023-10-31 — — US disclosed
US-11802120-B2 Fused cyclic urea derivatives as CRHR2 antagonist RAQUALIA PHARMA INC. (JP) 2023-10-31 — — US disclosed
EP-4183774-A1 SULFONYLUREA DERIVATIVE AND MEDICAL USES THEREOF Shanghai Senhui Medicine Co., Ltd. (CN) 2023-05-24 — — EP disclosed
EP-4183774-A1 SULFONYLUREA DERIVATIVE AND MEDICAL USES THEREOF Shanghai Senhui Medicine Co., Ltd. (CN) 2023-05-24 — — EP disclosed
CN-100395234-C Novel CB1 receptor inverse agonists HOFFMANN LA ROCHE (CH) 2008-06-18 — — CN disclosed
US-20080058335-A1 NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF ABBVIE INC. 2008-03-06 — — US disclosed
WO-2007140385-A2 THIAZOLE COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF ABBOTT LABORATORIES (US) 2007-12-06 — — WO disclosed
US-7294644-B2 CB 1 receptor inverse agonists HOFFMANN-LA ROCHE INC. (US) 2007-11-13 — — US disclosed
US-20070238754-A1 Novel CB 1 receptor inverse agonists MAYWEG ALEXANDER 2007-10-11 — — US disclosed
CN-101012193-A Novel CB 1 receptour inverse agonists HOFFMANN LA ROCHE (CH) 2007-08-08 — — CN disclosed
CN-1735593-A Novel CB1 receptor inverse agonists HOFFMANN LA ROCHE (CH) 2006-02-15 — — CN disclosed
EP-1583742-A1 NOVEL CB 1 RECEPTOUR INVERSE AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2005-10-12 — — EP disclosed
US-20040167129-A1 Novel CB 1 receptor inverse agonists HOFFMANN-LA ROCHE INC. 2004-08-26 — — US disclosed
WO-2004060870-A1 NOVEL CB 1 RECEPTOUR INVERSE AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2004-07-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240018103-A1 3-HYDROXYOXINDOLE DERIVATIVES AS CRHR2 ANTAGONIST CRHR2, CRHR1, CRH TSHR 295/4885GAA 3932/4885ALDH1A1 4326/4885
US-12492166-B2 Sulfonylurea derivative and medical uses thereof PYGB, ATP6V1B2, GLP1R TSHR 1643/4885GAA 508/4885ALDH1A1 802/4885
US-20040167129-A1 Novel CB 1 receptor inverse agonists CNR1, CNR2, ARRB1 TSHR 444/4885GAA 4346/4885ALDH1A1 1464/4885
US-20070238754-A1 Novel CB 1 receptor inverse agonists CNR1, CNR2, GPR139 TSHR 372/4885GAA 4342/4885ALDH1A1 1498/4885
US-11802120-B2 Fused cyclic urea derivatives as CRHR2 antagonist CRHR2, CRHR1, CRH TSHR 229/4885GAA 3441/4885ALDH1A1 4726/4885
US-20230348371-A1 SULFONYLUREA DERIVATIVE AND MEDICAL USES THEREOF PYGB, ATP6V1B2, GLP1R TSHR 1643/4885GAA 508/4885ALDH1A1 802/4885
US-20080058335-A1 NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF CNR1, CNR2, OPRL1 TSHR 334/4885GAA 2192/4885ALDH1A1 914/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.