Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NSD2 | O96028 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.46 |
| ▸ | LIPE | Q05469 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2438835 | 0.83 | NPC1 (0.50) | TDP1POLBSMN1; SMN2MAOB | |
| SCHEMBL2492367 | 0.80 | SRD5A2 (0.52) | L3MBTL1MAPTTDP1POLBSMN1; SMN2 | |
| SCHEMBL9012908 | 0.80 | L3MBTL1 (0.43) | L3MBTL1MAPTTDP1MAPK1POLB | |
| SCHEMBL9785325 | 0.80 | L3MBTL1 (0.43) | L3MBTL1MAPTTDP1MAPK1POLB | |
| SCHEMBL9653085 | 0.80 | LOXL2 (0.48) | L3MBTL1POLBNSD2ABL1PPARG | |
| SCHEMBL71120 | 0.80 | GSTP1 (0.44) | L3MBTL1MAPTTDP1POLBSMN1; SMN2 | |
| SCHEMBL13462058 | 0.80 | LMNA (0.50) | L3MBTL1MAPTTDP1MAPK1POLB | |
| SCHEMBL9012870 | 0.80 | HTR2A (0.43) | L3MBTL1MAPTTDP1MAPK1POLB | |
| SCHEMBL10897164 | 0.80 | L3MBTL1 (0.45) | L3MBTL1MAPTTDP1POLBSMN1; SMN2 | |
| SCHEMBL2116953 | 0.79 | L3MBTL1 (0.42) | L3MBTL1MAPTTDP1MAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110218207-B | Coumarin hybrid pyridone compound with iron chelation and monoamine oxidase B inhibition activity and preparation and application thereof | 浙江工业大学 | 2020-12-25 | — | — | CN | disclosed |
| US-9938240-B2 | Fluorinated derivatives of 3-hydroxypyridin-4-ones | APOTEX INC. (CA) | 2018-04-10 | — | — | US | disclosed |
| US-20170247329-A1 | \"Fluorinated Derivatives of 3-Hydroxypyridin-4-Ones\ | APOTEX TECHNOLOGIES INC. (CA) | 2017-08-31 | — | — | US | disclosed |
| US-20170088518-A1 | Fluorinated Derivatives of 3-Hydroxypyridin-4-Ones | THE BANK OF NOVA SCOTIA (CA) | 2017-03-30 | — | — | US | disclosed |
| US-9550733-B2 | Fluorinated derivatives of 3-hydroxypyridin-4-ones | APOTEX TECHNOLOGIES INC. (CA) | 2017-01-24 | — | — | US | disclosed |
| EP-2134688-B1 | FLUORINATED DERIVATIVES OF DEFERIPRONE | APOTEX TECHNOLOGIES INC (CA) | 2016-10-05 | — | — | EP | disclosed |
| US-20160083346-A1 | Fluorinated Derivatives of 3-Hydroxypyridin-4-Ones | APOTEX TECHNOLOGIES INC. (CA) | 2016-03-24 | — | — | US | disclosed |
| CN-103601673-B | The fluorinated derivatives of 3-pyridone-4-ketone | APOTEX TECHNOLOGIES INC. (CA) | 2016-03-16 | — | — | CN | disclosed |
| US-20150335626-A1 | FLUORINATED DERIVATIVES OF 3-HYDROXYPYRIDIN-4-ONES | APOTEX INC. (CA) | 2015-11-26 | — | — | US | disclosed |
| US-20150274665-A1 | FLUORINATED DERIVATIVES OF 3-HYDROXYPYRIDIN-4-ONES | FLORIDA TURBINE TECHNOLOGIES, INC. | 2015-10-01 | — | — | US | disclosed |
| EP-2448922-B1 | FLUORINATED DERIVATIVES OF 3-HYDROXYPYRIDIN-4-ONES | APOTEX TECHNOLOGIES INC (CA) | 2014-08-20 | — | — | EP | disclosed |
| CN-102712591-B | Fluorinated derivatives of 3-hydroxypyridin-4-ones | APOTEX TECHNOLOGIES INC | 2014-06-25 | — | — | CN | disclosed |
| US-8673943-B2 | Fluorinated derivatives of deferiprone | APOTEX TECHNOLOGIES INC. (CA) | 2014-03-18 | — | — | US | disclosed |
| CN-103601673-A | Fluorinated derivatives of 3-hydroxypyridin-4-ones | APOTEX TECHNOLOGIES INC | 2014-02-26 | — | — | CN | disclosed |
| US-20120270882-A1 | FLUORINATED DERIVATES OF 3-HYDROXYPYRIDIN-4-ONES | APOTEX TECHNOLOGIES INC. (CA) | 2012-10-25 | — | — | US | disclosed |
| US-20120095061-A1 | Fluorinated Derivatives of Deferiprone | APOTEX TECHNOLOGIES INC. (CA) | 2012-04-19 | — | — | US | disclosed |
| US-8026261-B2 | neurodegenerative diseases; to remove free iron or iron accumulation in neural tissues; iron chelators; improved chemical stability, penetration through blood brain barrier; reacting 3-hydroxy-4-pyridinone/3-hydroxy-4-pyranone derivatives; 1-cyclopropyl-2-difluoromethyl-5-hydroxy-1H-pyridin-4-one | APOTEX TECHNOLOGIES INC. (CA) | 2011-09-27 | — | — | US | disclosed |
| EP-2134688-A1 | FLUORINATED DERIVATIVES OF DEFERIPRONE | Apotex Technologies Inc. (CA) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008116301-A1 | FLUORINATED DERIVATIVES OF DEFERIPRONE | APOTEX TECHNOLOGIES INC. (CA) | 2008-10-02 | — | — | WO | disclosed |
| US-20080242706-A1 | Fluorinated derivatives of deferiprone | APOTEX TECHNOLOGIES INC. | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160083346-A1 | Fluorinated Derivatives of 3-Hydroxypyridin-4-Ones | FH, FECH, FPGS | L3MBTL1 2478/4885MAPT 1342/4885TDP1 817/4885 |
| US-20080242706-A1 | Fluorinated derivatives of deferiprone | SLC40A1, TFRC, FECH | L3MBTL1 3150/4885MAPT 199/4885TDP1 703/4885 |
| US-20150335626-A1 | FLUORINATED DERIVATIVES OF 3-HYDROXYPYRIDIN-4-ONES | FH, FECH, TFRC | L3MBTL1 2457/4885MAPT 2056/4885TDP1 1040/4885 |
| US-20120270882-A1 | FLUORINATED DERIVATES OF 3-HYDROXYPYRIDIN-4-ONES | FH, FECH, FTH1 | L3MBTL1 2399/4885MAPT 1822/4885TDP1 1079/4885 |
| US-20120095061-A1 | Fluorinated Derivatives of Deferiprone | SLC40A1, TFRC, FECH | L3MBTL1 3150/4885MAPT 199/4885TDP1 703/4885 |
| US-20170088518-A1 | Fluorinated Derivatives of 3-Hydroxypyridin-4-Ones | FH, FECH, FPGS | L3MBTL1 2228/4885MAPT 1549/4885TDP1 966/4885 |
| US-20170247329-A1 | \"Fluorinated Derivatives of 3-Hydroxypyridin-4-Ones\ | FH, FECH, FPGS | L3MBTL1 2433/4885MAPT 1732/4885TDP1 822/4885 |
| US-20150274665-A1 | FLUORINATED DERIVATIVES OF 3-HYDROXYPYRIDIN-4-ONES | FH, FECH, TFRC | L3MBTL1 2457/4885MAPT 2056/4885TDP1 1040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.