Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | TMIGD3 | P0DMS9 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21225297 | 0.83 | RORC (0.51) | RORCMAPTNPC1USP2 | |
| SCHEMBL21241931 | 0.82 | MAPT (0.55) | MAPTNPC1USP2 | |
| SCHEMBL21241888 | 0.81 | MAPT (0.40) | PDE5ACSNK1DPDE1APDE1BPDE1C | |
| SCHEMBL21241803 | 0.81 | CSNK2A2 (0.41) | PDE5ACSNK1DPDE1APDE1BPDE1C | |
| SCHEMBL21241981 | 0.80 | ADORA3 (0.54) | POLBMAPTL3MBTL1 | |
| SCHEMBL21241854 | 0.80 | MAPT (0.48) | MAPTNPC1 | |
| SCHEMBL21242061 | 0.80 | POLB (0.52) | POLBMAPTL3MBTL1NPC1USP2 | |
| SCHEMBL21241887 | 0.80 | SIRT5 (0.41) | CSNK1DPOLBMAPT | |
| SCHEMBL21241789 | 0.80 | MAPT (0.47) | POLBMAPTL3MBTL1NPC1 | |
| SCHEMBL21241795 | 0.79 | MAPT (0.45) | POLBMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019152437-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2019-08-08 | — | — | WO | disclosed |