Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAD52 | P43351 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6399729 | 1.00 | DPP4 (0.32) | DPP4KDM4EGAAMAPTRAD52 | |
| SCHEMBL2127142 | 0.99 | DPP4 (0.32) | DPP4KDM4EGAAMAPTRAD52 | |
| Hydrochloric Acid SCHEMBL2126545 | 0.87 | GAA (0.36) | DPP4GAARAD52 | |
| SCHEMBL2127202 | 0.86 | GAA (0.37) | DPP4GAARAD52 | |
| Hydrochloric Acid SCHEMBL4628464 | 0.84 | MEN1 (0.38) | DPP4GAA | |
| Hydrochloric Acid SCHEMBL6495609 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL2126873 | 0.78 | — | — | |
| SCHEMBL2927488 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL2537577 | 0.77 | MAPT (0.36) | KDM4EGAAMAPTRAD52GFER | |
| Hydrochloric Acid SCHEMBL6331452 | 0.77 | MAPT (0.36) | KDM4EGAAMAPTRAD52GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1348695-B1 | Derivatives of paraphenylene diamine with pyrrolidine groups substituted by cationic radicals and their use for dyeing keratinic fibre | OREAL (FR) | 2012-04-25 | — | — | EP | claimed |
| US-8043385-B2 | Composition oxidation colouring of keratinic fibres, containing a cationic cellulose ether, a metasilicate and oxidation dyes, method for oxidation colouring and uses thereof | L'OREAL S.A. (FR) | 2011-10-25 | — | — | US | claimed |
| US-20100263138-A1 | COMPOSITION OXIDATION COLOURING OF KERATINIC FIBRES, CONTAINING A CATIONIC CELLULOSE ETHER, A METASILICATE AND OXIDATION DYES, METHOD FOR OXIDATION COLOURING AND USES THEREOF | L'OREAL S.A. (FR) | 2010-10-21 | — | — | US | claimed |
| EP-1428515-B1 | Dyeing composition comprising a tertiary paraphenylenediamine containing a pyrrolidine, and a surfactant; methods and uses | OREAL (FR) | 2008-07-02 | — | — | EP | claimed |
| EP-1428514-B1 | Dyeing composition comprising a tertiary paraphenylenediamine containing a pyrrolidine, a tertiary paraphenylenediamine and a benzomorpholine coupler; method and use | OREAL (FR) | 2007-09-19 | — | — | EP | claimed |
| US-7101406-B2 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a heterocyclic cationic direct dye, methods and uses | L'OREAL (FR) | 2006-09-05 | — | — | US | claimed |
| US-20060112502-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a heterocyclic cationic direct dye, methods and uses | L'OREAL (FR) | 2006-06-01 | — | — | US | claimed |
| US-6946005-B2 | Pyrrolidinyl-substituted para-phenylenediamine derivatives substituted with a cationic radical, and use of these derivatives for dyeing keratin fibers | L'OREAL S.A. (FR) | 2005-09-20 | — | — | US | claimed |
| US-20040250356-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a particular pearlescent or opacifying agent, methods and uses | L'OREAL (FR) | 2004-12-16 | — | — | US | claimed |
| US-20040231068-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a cationic polymer, methods and uses | L'OREAL (FR) | 2004-11-25 | — | — | US | claimed |
| US-20040221399-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a heterocyclic cationic direct dye, methods and uses | L'OREAL (FR) | 2004-11-11 | — | — | US | claimed |
| US-20040216244-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and an organic diacid, methods and uses | L'OREAL (FR) | 2004-11-04 | — | — | US | claimed |
| US-20040216245-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a para-aminophenol, methods and uses | L'OREAL (FR) | 2004-11-04 | — | — | US | claimed |
| US-20040216246-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a polymer containing a fatty chain, methods and uses | L'OREAL (FR) | 2004-11-04 | — | — | US | claimed |
| US-20040216243-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a surfactant, processes therefor and uses thereof | L'OREAL (FR) | 2004-11-04 | — | — | US | claimed |
| US-20040211010-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a polyol ester, processes therefor and uses thereof | L'OREAL (FR) | 2004-10-28 | — | — | US | claimed |
| US-20040205904-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a vitamin derivative, processes therefor and uses thereof | L'OREAL (FR) | 2004-10-21 | — | — | US | claimed |
| US-20040205903-A1 | Dyeing composition comprising a cationic pyrrolidine-based para-phenylenefiamine, a tertiary para-phenylenediamine and a benzomorpholine coupler, methods and uses | L'OREAL (FR) | 2004-10-21 | — | — | US | claimed |
| US-20040194227-A9 | Pyrrolidinyl-substituted para-phenylenediamine derivatives substituted with a cationic radical, and use of these derivatives for dyeing keratin fibres | L'OREAL S.A. (FR) | 2004-10-07 | — | — | US | claimed |
| US-20030229949-A1 | Pyrrolidinyl-substituted para-phenylenediamine derivatives substituted with a cationic radical, and use of these derivatives for dyeing keratin fibres | SABELLE STEPHANE (FR) | 2003-12-18 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040231068-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a cationic polymer, methods and uses | PHOSPHO1, KRT18, NUP205 | DPP4 3881/4885KDM4E 2371/4885GAA 3349/4885 |
| US-20060112502-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a heterocyclic cationic direct dye, methods and uses | KRT18, CDC73, NUP205 | DPP4 2362/4885KDM4E 1328/4885GAA 4728/4885 |
| US-20040205903-A1 | Dyeing composition comprising a cationic pyrrolidine-based para-phenylenefiamine, a tertiary para-phenylenediamine and a benzomorpholine coupler, methods and uses | CDC73, KRT18, PAH | DPP4 1964/4885KDM4E 1179/4885GAA 4851/4885 |
| US-20040216246-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a polymer containing a fatty chain, methods and uses | KRT18, PLIN5, PLIN1 | DPP4 2590/4885KDM4E 1845/4885GAA 4515/4885 |
| US-20040216245-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a para-aminophenol, methods and uses | KRT18, CDC73, NUP205 | DPP4 1333/4885KDM4E 1079/4885GAA 4611/4885 |
| US-20040211010-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a polyol ester, processes therefor and uses thereof | KRT18, PPHLN1, PKLR | DPP4 2327/4885KDM4E 1835/4885GAA 4341/4885 |
| US-20040250356-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a particular pearlescent or opacifying agent, methods and uses | KRT18, CDC73, PPHLN1 | DPP4 3697/4885KDM4E 2716/4885GAA 4764/4885 |
| US-20040221399-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a heterocyclic cationic direct dye, methods and uses | KRT18, CDC73, NUP205 | DPP4 2362/4885KDM4E 1328/4885GAA 4728/4885 |
| US-20100263138-A1 | COMPOSITION OXIDATION COLOURING OF KERATINIC FIBRES, CONTAINING A CATIONIC CELLULOSE ETHER, A METASILICATE AND OXIDATION DYES, METHOD FOR OXIDATION COLOURING AND USES THEREOF | KRT18, TUBB3, VIM | DPP4 4844/4885KDM4E 708/4885GAA 4088/4885 |
| US-20040194227-A9 | Pyrrolidinyl-substituted para-phenylenediamine derivatives substituted with a cationic radical, and use of these derivatives for dyeing keratin fibres | KRT18, VIM, CKAP4 | DPP4 2824/4885KDM4E 937/4885GAA 4822/4885 |
| US-20040216243-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a surfactant, processes therefor and uses thereof | KRT18, NOTUM, PHOSPHO1 | DPP4 3394/4885KDM4E 2696/4885GAA 3878/4885 |
| US-20040216244-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and an organic diacid, methods and uses | KRT18, CDC73, DDC | DPP4 2152/4885KDM4E 1832/4885GAA 4540/4885 |
| US-20030229949-A1 | Pyrrolidinyl-substituted para-phenylenediamine derivatives substituted with a cationic radical, and use of these derivatives for dyeing keratin fibres | KRT18, VIM, CKAP4 | DPP4 2824/4885KDM4E 937/4885GAA 4822/4885 |
| US-20040205904-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a vitamin derivative, processes therefor and uses thereof | KRT18, PPHLN1, PYCR1 | DPP4 2370/4885KDM4E 1936/4885GAA 4705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.