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SCHEMBL2129706

SCHEMBL2129706

COC(=O)Cc1ccc(B2OC(C)(C)C(C)(C)O2)c(F)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 1/20 0.43
▸ GAA P10253 1/20 0.43
▸ GFER P55789 1/20 0.43
▸ CYP4F2 P78329 1/20 0.40
▸ CYP4A11 Q02928 1/20 0.40
▸ PDK2 Q15119 1/20 0.40
▸ HSP90AB1 P08238 1/20 0.39
▸ HPGD P15428 2/20 0.38
▸ MAPT P10636 1/20 0.38
▸ TSHR P16473 1/20 0.38
▸ UCHL1 P09936 1/20 0.37
▸ ROCK1 Q13464 1/20 0.36
▸ SLC7A5 Q01650 1/20 0.36
▸ MEN1 O00255 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ TLR7 Q9NYK1 1/20 0.35
▸ NPC1 O15118 4/20 0.35
▸ RAB9A P51151 4/20 0.35
▸ SMN1; SMN2 Q16637 4/20 0.35
▸ TP53 P04637 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL136786 0.90 GAA (0.43) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL27144967 0.87 UCHL1 (0.43) ALDH1A1CYP4F2CYP4A11MAPTUCHL1
SCHEMBL12068166 0.86 MTNR1A (0.38) UCHL1ROCK1CXCR2
SCHEMBL14712147 0.85 ALDH1A1 (0.43) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL14881305 0.85 GAA (0.39) ALDH1A1GAAHPGDMAPTTSHR
SCHEMBL25734687 0.84 ALDH1A1 (0.46) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL30019267 0.84 ALDH1A1 (0.43) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL2131624 0.84 ALDH1A1 (0.43) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL23553199 0.84 UCHL1 (0.34) ALDH1A1HPGDTSHRUCHL1ROCK1
SCHEMBL16045701 0.84 F11 (0.40) ALDH1A1UCHL1ROCK1CXCR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12497382-B2 GLP-1R modulating compounds GILEAD SCIENCES, INC. (US) 2025-12-16 — — US disclosed
US-12421205-B2 GLP-1 receptor agonist HYUNDAI PHARM CO., LTD. (KR) 2025-09-23 — — US disclosed
EP-4069686-B1 GLP-1 RECEPTOR AGONIST HYUNDAI PHARM CO LTD (KR) 2025-01-22 — — EP disclosed
US-11970448-B2 Monomers capable of dimerizing in an aqueous solution, and methods of using same CORNELL UNIVERSITY (US) 2024-04-30 — — US disclosed
US-20230391747-A1 GLP-1R MODULATING COMPOUNDS GILEAD SCIENCES, INC. 2023-12-07 — — US disclosed
US-11702404-B2 GLP-1R modulating compounds GILEAD SCIENCES, INC. (US) 2023-07-18 — — US disclosed
US-11702404-B2 GLP-1R modulating compounds GILEAD SCIENCES, INC. (US) 2023-07-18 — — US disclosed
US-11702404-B2 GLP-1R modulating compounds GILEAD SCIENCES, INC. (US) 2023-07-18 — — US disclosed
US-20230051318-A1 GLP-1 RECEPTOR AGONIST HYUNDAI PHARM CO., LTD. (KR) 2023-02-16 — — US disclosed
CN-115279750-A GLP-1 receptor agonist, pharmaceutical composition containing same and preparation method thereof 株式会社LG化学 2022-11-01 — — CN disclosed
US-20120289520-A1 CHEMICAL COMPOUNDS 785 ASTRAZENECA AB (SE) 2012-11-15 — — US disclosed
US-8188092-B2 Substituted pyrazines as DGAT-1 inhibitors ASTRAZENECA AB (SE) 2012-05-29 — — US disclosed
US-8188092-B2 Substituted pyrazines as DGAT-1 inhibitors ASTRAZENECA AB (SE) 2012-05-29 — — US disclosed
US-8188092-B2 Substituted pyrazines as DGAT-1 inhibitors ASTRAZENECA AB (SE) 2012-05-29 — — US disclosed
EP-2443096-A1 PYRAZINE CARBOXAMIDES AS INHIBITORS OF DGAT1 AstraZeneca AB (SE) 2012-04-25 — — EP disclosed
US-20100324068-A1 CHEMICAL COMPOUNDS 785 ASTRAZENECA AB (SE) 2010-12-23 — — US disclosed
US-20100324068-A1 CHEMICAL COMPOUNDS 785 ASTRAZENECA AB (SE) 2010-12-23 — — US disclosed
US-20100324068-A1 CHEMICAL COMPOUNDS 785 ASTRAZENECA AB (SE) 2010-12-23 — — US disclosed
WO-2010146395-A1 PYRAZINE CARBOXAMIDES AS INHIBITORS OF DGAT1 ASTRAZENECA AB (SE) 2010-12-23 — — WO disclosed
WO-2010146395-A1 PYRAZINE CARBOXAMIDES AS INHIBITORS OF DGAT1 ASTRAZENECA AB (SE) 2010-12-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11970448-B2 Monomers capable of dimerizing in an aqueous solution, and methods of using same CALCOCO2, MDN1, MBNL1 ALDH1A1 4582/4885GAA 4698/4885GFER 229/4885
US-11702404-B2 GLP-1R modulating compounds GLP1R, GIPR, GPR119 ALDH1A1 3556/4885GAA 1038/4885GFER 3666/4885
US-20100324068-A1 CHEMICAL COMPOUNDS 785 GPBAR1, DGAT1, GPR119 ALDH1A1 699/4885GAA 200/4885GFER 2761/4885
US-20230051318-A1 GLP-1 RECEPTOR AGONIST GLP1R, GIPR, GCGR ALDH1A1 2082/4885GAA 1808/4885GFER 2300/4885
US-12421205-B2 GLP-1 receptor agonist GLP1R, GIPR, GCGR ALDH1A1 2082/4885GAA 1808/4885GFER 2300/4885
US-20230391747-A1 GLP-1R MODULATING COMPOUNDS GLP1R, GIPR, GPR119 ALDH1A1 3556/4885GAA 1038/4885GFER 3666/4885
US-20120289520-A1 CHEMICAL COMPOUNDS 785 DGAT1, DGAT2, SLC5A1 ALDH1A1 208/4885GAA 46/4885GFER 2954/4885
US-12497382-B2 GLP-1R modulating compounds GLP1R, GIPR, GPR119 ALDH1A1 3556/4885GAA 1038/4885GFER 3666/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.