Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.49 |
| ▸ | NCF1 | P14598 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319121 | 0.75 | CCR2 (0.49) | HRH3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11139655 | 0.75 | HRH3 (0.69) | HRH3NCF1ALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7404903 | 0.74 | HRH3 (0.67) | HRH3NCF1ALDH1A1MEN1KMT2A | |
| SCHEMBL4547890 | 0.74 | HRH3 (0.65) | HRH3NCF1ALDH1A1MEN1KMT2A | |
| SCHEMBL4547912 | 0.71 | ALDH1A1 (0.59) | HRH3NCF1ALDH1A1KDM4EHTT | |
| SCHEMBL10178419 | 0.68 | HRH3 (0.62) | HRH3NCF1ALDH1A1MEN1KMT2A | |
| SCHEMBL17335871 | 0.68 | HRH3 (0.66) | HRH3ALDH1A1KDM4EHTTSMN1; SMN2 | |
| SCHEMBL21730434 | 0.67 | NCF1 (0.66) | HRH3NCF1ALDH1A1MEN1KMT2A | |
| SCHEMBL10178474 | 0.67 | HRH3 (0.59) | HRH3NCF1ALDH1A1MEN1KMT2A | |
| SCHEMBL6227511 | 0.66 | HRH3 (0.57) | HRH3NCF1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10745356-B2 | Compositions and methods for treating tuberculosis | THE BROAD INSTITUTE, INC. (US) | 2020-08-18 | — | — | US | disclosed |
| US-20190284140-A1 | COMPOSITIONS AND METHODS FOR TREATING TUBERCULOSIS | THE BROAD INSTITUTE, INC. | 2019-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10745356-B2 | Compositions and methods for treating tuberculosis | C5, IFNG, TERT | HRH3 2194/4885NCF1 1635/4885ALDH1A1 1848/4885 |
| US-20190284140-A1 | COMPOSITIONS AND METHODS FOR TREATING TUBERCULOSIS | C5, IFNG, TERT | HRH3 2194/4885NCF1 1635/4885ALDH1A1 1848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.