Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 13/20 | 0.42 |
| ▸ | CTSS | P25774 | 3/20 | 0.40 |
| ▸ | CTSK | P43235 | 3/20 | 0.40 |
| ▸ | LPL | P06858 | 2/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2146769 | 0.94 | CTSS (0.42) | S1PR1CTSSCTSKLPLLIPG | |
| SCHEMBL18704586 | 0.88 | LPL (0.42) | S1PR1CTSSCTSKLPLLIPG | |
| SCHEMBL22150433 | 0.87 | LPL (0.45) | S1PR1CTSSCTSKLPLLIPG | |
| SCHEMBL6901029 | 0.87 | LPL (0.36) | S1PR1LPLLIPGAAK1DGAT1 | |
| SCHEMBL16499739 | 0.85 | RXRA (0.42) | CTSSCTSKLPLLIPGAAK1 | |
| SCHEMBL2947619 | 0.85 | LPL (0.48) | S1PR1CTSSCTSKLPLLIPG | |
| SCHEMBL6897919 | 0.85 | KDM4E (0.41) | S1PR1LPLLIPGAAK1DGAT1 | |
| SCHEMBL28553153 | 0.84 | THRA (0.43) | CTSSCTSKLPLLIPGAAK1 | |
| SCHEMBL20361068 | 0.83 | LPL (0.45) | S1PR1LPLLIPG | |
| SCHEMBL3192898 | 0.83 | LIPG (0.45) | LPLLIPGAAK1DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2682448-B1 | POLYMERISABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS | MERCK PATENT GMBH (DE) | 2016-04-20 | — | — | EP | disclosed |
| US-9133395-B2 | Polymerizable compounds and the use thereof in liquid-crystal displays | MERCK PATENT GMBH (DE) | 2015-09-15 | — | — | US | disclosed |
| US-9133395-B2 | Polymerizable compounds and the use thereof in liquid-crystal displays | MERCK PATENT GMBH (DE) | 2015-09-15 | — | — | US | disclosed |
| US-9115126-B2 | 1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile derivatives | MERCK SHARP & DOHME B.V. (NL) | 2015-08-25 | — | — | US | disclosed |
| US-9115126-B2 | 1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile derivatives | MERCK SHARP & DOHME B.V. (NL) | 2015-08-25 | — | — | US | disclosed |
| EP-2523954-B1 | 1H-[1,2,3]TRIAZOLO[4,5-C]PYRIDINE-4- CARBONITRILE DERIVATIVES AS CATHEPSIN S INHIBITORS | MERCK SHARP & DOHME (NL) | 2014-04-16 | — | — | EP | disclosed |
| EP-2523954-A1 | 1H-[1,2,3]TRIAZOLO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES | MSD Oss B.V. (NL) | 2012-11-21 | — | — | EP | disclosed |
| US-20120283239-A1 | 1H-[1,2,3]TRIAZOLO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES | MSD OSS B.V. (NL) | 2012-11-08 | — | — | US | disclosed |
| US-20120283239-A1 | 1H-[1,2,3]TRIAZOLO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES | MSD OSS B.V. (NL) | 2012-11-08 | — | — | US | disclosed |
| WO-2011086125-A1 | 1H-[1,2,3]TRIAZOLO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES | N.V. ORGANON (NL) | 2011-07-21 | — | — | WO | disclosed |
| WO-2011086125-A1 | 1H-[1,2,3]TRIAZOLO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES | N.V. ORGANON (NL) | 2011-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120283239-A1 | 1H-[1,2,3]TRIAZOLO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES | CTSS, CTSV, CTSZ | S1PR1 1006/4885CTSS 1/4885CTSK 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.