Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2379044 | 0.84 | ALDH1A1 (0.37) | TSHRALDH1A1 | |
| SCHEMBL331750 | 0.75 | TSHR (0.41) | TSHRTHRBALDH1A1 | |
| SCHEMBL1284120 | 0.75 | TSHR (0.41) | TSHRTHRBALDH1A1 | |
| SCHEMBL331866 | 0.74 | TSHR (0.39) | TSHRTHRBALDH1A1 | |
| SCHEMBL18171345 | 0.74 | TSHR (0.42) | TSHRTHRBALDH1A1 | |
| SCHEMBL94906 | 0.74 | TSHR (0.68) | TSHRTHRBALDH1A1 | |
| SCHEMBL17727845 | 0.74 | TSHR (0.44) | TSHRTHRBALDH1A1 | |
| SCHEMBL137371 | 0.73 | TSHR (0.61) | TSHRTHRBALDH1A1 | |
| SCHEMBL19998240 | 0.73 | TSHR (0.65) | TSHRTHRBALDH1A1 | |
| SCHEMBL29011418 | 0.72 | TSHR (0.45) | TSHRTHRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342588-B9 | IONIC SILICONE HYDROGELS HAVING IMPROVED HYDROLYTIC STABILITY | JOHNSON & JOHNSON VISION CARE (US) | 2024-10-02 | — | — | EP | disclosed |
| EP-2342588-B1 | IONIC SILICONE HYDROGELS HAVING IMPROVED HYDROLYTIC STABILITY | JOHNSON & JOHNSON VISION CARE (US) | 2024-07-03 | — | — | EP | disclosed |
| US-9851472-B2 | Silicone-based hydrophilic copolymer and hydrogel compositions comprising the same | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2017-12-26 | — | — | US | disclosed |
| US-20160282517-A1 | SILICONE-BASED HYDROPHILIC COPOLYMER AND HYDROGEL COMPOSITIONS COMPRISING THE SAME | MOMENTIVE PERFORMANCE MATERIALS INC. | 2016-09-29 | — | — | US | disclosed |
| US-9260544-B2 | Ionic silicone hydrogels having improved hydrolytic stability | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2016-02-16 | — | — | US | disclosed |
| US-9101667-B2 | Ionic silicone hydrogels comprising pharmaceutical and/or neuticeutical components and having improved hydrolytic stability | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2015-08-11 | — | — | US | disclosed |
| US-20140329859-A1 | IONIC SILICONE HYDROGELS COMPRISING PHARMACEUTICAL AND/OR NEUTICEUTICAL COMPONENTS AND HAVING IMPROVED HYDROLYTIC STABILITY | JOHNSON & JOHNSON VISION CARE (US) | 2014-11-06 | — | — | US | disclosed |
| US-20140296440-A1 | IONIC SILICONE HYDROGELS HAVING IMPROVED HYDROLYTIC STABILITY | JOHNSON & JOHNSON VISION CARE (US) | 2014-10-02 | — | — | US | disclosed |
| US-8815972-B2 | Ionic silicone hydrogels having improved hydrolytic stability | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2014-08-26 | — | — | US | disclosed |
| US-20130261215-A1 | IONIC SILICONE HYDROGELS HAVING IMPROVED HYDROLYTIC STABILITY | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2013-10-03 | — | — | US | disclosed |
| US-20130203812-A1 | IONIC SILICONE HYDROGELS COMPRISING PHARMACEUTICAL AND/OR NUTRICEUTICAL COMPONENTS AND HAVING IMPROVED HYDROLYTIC STABILITY | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2013-08-08 | — | — | US | disclosed |
| US-8470906-B2 | Ionic silicone hydrogels having improved hydrolytic stability | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| EP-2342588-A1 | IONIC SILICONE HYDROGELS HAVING IMPROVED HYDROLYTIC STABILITY | Johnson & Johnson Vision Care, Inc. (US) | 2011-07-13 | — | — | EP | disclosed |
| US-20100249356-A1 | IONIC SILICONE HYDROGELS HAVING IMPROVED HYDROLYTIC STABILITY | JOHNSON & JOHNSON VISION CARE, INC. | 2010-09-30 | — | — | US | disclosed |
| WO-2010039653-A1 | IONIC SILICONE HYDROGELS HAVING IMPROVED HYDROLYTIC STABILITY | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130203812-A1 | IONIC SILICONE HYDROGELS COMPRISING PHARMACEUTICAL AND/OR NUTRICEUTICAL COMPONENTS AND HAVING IMPROVED HYDROLYTIC STABILITY | IGFBP6, IGFBP1, IGFBP2 | TSHR 2878/4885THRB 2874/4885ALDH1A1 3840/4885 |
| US-20160282517-A1 | SILICONE-BASED HYDROPHILIC COPOLYMER AND HYDROGEL COMPOSITIONS COMPRISING THE SAME | RAD51, PLOD1, ILK | TSHR 1598/4885THRB 1771/4885ALDH1A1 1954/4885 |
| US-20140329859-A1 | IONIC SILICONE HYDROGELS COMPRISING PHARMACEUTICAL AND/OR NEUTICEUTICAL COMPONENTS AND HAVING IMPROVED HYDROLYTIC STABILITY | PIGS, PTMS, INHA | TSHR 1582/4885THRB 1620/4885ALDH1A1 4175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.