Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | NEK2 | P51955 | 1/20 | 0.32 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2848631 | 0.89 | KDM4E (0.33) | HTR6KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL29354371 | 0.87 | HTR6 (0.36) | HTR6KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL21788 | 0.87 | HTR6 (0.36) | HTR6KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL29353225 | 0.87 | HTR6 (0.36) | HTR6KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4988734 | 0.85 | HTR6 (0.34) | HTR6ALDH1A1GAAMAPTTSHR | |
| Bromide SCHEMBL1030113 | 0.84 | HTR6 (0.35) | HTR6ALDH1A1MAPTLMNA | |
| SCHEMBL29378142 | 0.84 | MAPT (0.41) | HTR6KDM4EALDH1A1GAAMAPT | |
| SCHEMBL14736169 | 0.84 | MAPT (0.41) | HTR6KDM4EALDH1A1GAAMAPT | |
| SCHEMBL19469290 | 0.83 | HTR6 (0.34) | HTR6ALDH1A1MAPTLMNA | |
| SCHEMBL32667778 | 0.83 | NSD2 (0.40) | HTR6ALDH1A1MAPTROCK2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686495-B2 | IN PRESENCE OF PALLADIUM CATALYST; USEFUL IN PRODUCING CHEMICAL INTERMEDIATES FOR PHARMACEUTICALS, OPTICAL BRIGHTENING AGENTS AND AGROCHEMICALS | OMG AG & CO KG (DE) | 2004-02-03 | — | — | US | claimed |
| US-20020107426-A1 | Process for the preparation of mono-, bi- or poly- functional biaryls | UMICORE AG & CO. KG (DE) | 2002-08-08 | — | — | US | claimed |
| EP-1199292-A1 | Process for the production of mono-, bi- or polyfunctional biaryls | OMG AG & Co. KG (DE) | 2002-04-24 | — | — | EP | claimed |
| US-20260021192-A1 | PROTEINS HAVING A COVALENT WARHEAD | TOPAZ THERAPEUTICS INC (US) | 2026-01-22 | — | — | US | disclosed |
| US-20240424116-A1 | Pegylated-AU(III) Reagents for Rapid Cysteine S-Arylation of Biomolecules | UNIV CALIFORNIA (US) | 2024-12-26 | — | — | US | disclosed |
| US-20130253185-A1 | NOVEL CATALYSTS | DALHOUSIE UNIVERSITY (CA) | 2013-09-26 | — | — | US | disclosed |
| US-20130253185-A1 | NOVEL CATALYSTS | DALHOUSIE UNIVERSITY (CA) | 2013-09-26 | — | — | US | disclosed |
| US-8236947-B2 | Quinoline derivatives and their use as 5-HT6 ligands | GLAXO GROUP LIMITED (GB) | 2012-08-07 | — | — | US | disclosed |
| EP-2120950-B1 | USE OF QUINOLINE DERIVATIVES IN THE TREATMENT OF PAIN | GLAXO GROUP LTD (GB) | 2012-07-04 | — | — | EP | disclosed |
| WO-2012068335-A2 | NOVEL CATALYSTS | DALHOUSIE UNIVERSITY (CA) | 2012-05-24 | — | — | WO | disclosed |
| US-20110237792-A1 | QUINOLINE DERIVATIVES AND THEIR USE AS 5-HT6 LIGANDS | GLAXO GROUP LIMITED | 2011-09-29 | — | — | US | disclosed |
| US-20050124628-A1 | Novel compounds | ROIVANT NEUROSCIENCES LTD. (BM) | 2005-06-09 | — | — | US | disclosed |
| WO-2005030724-A1 | PIPERAZINYL-QUINOLINE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-04-07 | — | — | WO | disclosed |
| WO-2005021530-A1 | 8- (1-PIPERAZINYL)- QUINOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-03-10 | — | — | WO | disclosed |
| EP-1497266-A2 | QUINOLINE DERIVATIVES AND THEIR USE AS 5-HT6 LIGANDS | GLAXO GROUP LIMITED (GB) | 2005-01-19 | — | — | EP | disclosed |
| WO-2004080986-A1 | PHENYL SULFONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2004-09-23 | — | — | WO | disclosed |
| US-6686495-B2 | IN PRESENCE OF PALLADIUM CATALYST; USEFUL IN PRODUCING CHEMICAL INTERMEDIATES FOR PHARMACEUTICALS, OPTICAL BRIGHTENING AGENTS AND AGROCHEMICALS | OMG AG & CO KG (DE) | 2004-02-03 | — | — | US | disclosed |
| WO-2003080580-A2 | QUINOLINE DERIVATIVES AND THEIR USE AS 5-HT6 LIGANDS | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |
| US-20020107426-A1 | Process for the preparation of mono-, bi- or poly- functional biaryls | UMICORE AG & CO. KG (DE) | 2002-08-08 | — | — | US | disclosed |
| EP-1199292-A1 | Process for the production of mono-, bi- or polyfunctional biaryls | OMG AG & Co. KG (DE) | 2002-04-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124628-A1 | Novel compounds | NLN, ATP6V1B2, CHRNA2 | HTR6 111/4885KDM4E 2860/4885ALDH1A1 2947/4885 |
| US-20240424116-A1 | Pegylated-AU(III) Reagents for Rapid Cysteine S-Arylation of Biomolecules | LNPEP, PTMS, EGFR | HTR6 3981/4885KDM4E 4651/4885ALDH1A1 2594/4885 |
| US-20110237792-A1 | QUINOLINE DERIVATIVES AND THEIR USE AS 5-HT6 LIGANDS | HTR6, HTR1A, HTR7 | HTR6 1/4885KDM4E 4169/4885ALDH1A1 2401/4885 |
| US-20260021192-A1 | PROTEINS HAVING A COVALENT WARHEAD | RIOX2, ORC3, DCLRE1A | HTR6 4206/4885KDM4E 3880/4885ALDH1A1 3714/4885 |
| US-20020107426-A1 | Process for the preparation of mono-, bi- or poly- functional biaryls | CYP4F3, CYP4F2, CYP2F1 | HTR6 4072/4885KDM4E 2972/4885ALDH1A1 714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.