Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22031711 | 0.87 | LMNA (0.43) | KMT2APOLBLMNAHSD11B1EPHX2 | |
| SCHEMBL28753553 | 0.84 | MGLL (0.52) | KMT2APOLBLMNAMEN1HSD11B1 | |
| SCHEMBL27733598 | 0.84 | LMNA (0.57) | KMT2APOLBLMNAMEN1HSD11B1 | |
| SCHEMBL27713229 | 0.82 | GAA (0.55) | KMT2APOLBLMNAGAAMEN1 | |
| SCHEMBL28422447 | 0.81 | HTT (0.47) | KMT2APOLBGRM3GRM5GAA | |
| SCHEMBL28238844 | 0.81 | KMT2A (0.46) | KMT2APOLBLMNAMEN1ABL1 | |
| SCHEMBL27713245 | 0.78 | RAB9A (0.53) | KMT2APOLBLMNAGRM5GAA | |
| SCHEMBL19891310 | 0.77 | NAMPT (0.60) | KMT2AGRM3MEN1ABL1RIN1 | |
| SCHEMBL27713265 | 0.76 | SFRP1 (0.46) | KMT2APOLBLMNAL3MBTL3 | |
| SCHEMBL22031683 | 0.76 | GRM5 (0.51) | KMT2APOLBGRM3GRM5GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3891148-A1 | RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | Sunshine Lake Pharma Co., Ltd. (CN) | 2021-10-13 | — | — | EP | disclosed |
| WO-2020114494-A1 | RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2020-06-11 | — | — | WO | disclosed |