Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.92 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | S100A4 | P26447 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1101208 | 0.96 | TSHR (1.00) | TSHRTDP1ALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL146895 | 0.96 | TSHR (1.00) | TSHRTDP1ALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL29359563 | 0.96 | TSHR (1.00) | TSHRTDP1ALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL11696134 | 0.94 | TSHR (0.96) | TSHRTDP1ALDH1A1SMN1; SMN2HSD17B10 | |
| Magnesium SCHEMBL11696142 | 0.94 | TSHR (0.96) | TSHRTDP1ALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL8717819 | 0.94 | TSHR (0.96) | TSHRTDP1ALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL28589645 | 0.94 | TSHR (0.96) | TSHRTDP1ALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL31188803 | 0.94 | TSHR (0.96) | TSHRTDP1ALDH1A1SMN1; SMN2HSD17B10 | |
| Fluoride SCHEMBL28054250 | 0.94 | TSHR (0.96) | TSHRTDP1ALDH1A1SMN1; SMN2HSD17B10 | |
| O-Xylene SCHEMBL28588420 | 0.92 | TSHR (0.92) | TSHRTDP1ALDH1A1SMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1854160-A2 | REDOX-ACTIVE STRUCTURES AND DEVICES UTILIZING THE SAME | YEDA RESEARCH AND DEVELOPMENT CO., LTD. (IL) | 2007-11-14 | — | — | EP | claimed |
| WO-2006085319-A2 | REDOX-ACTIVE STRUCTURES AND DEVICES UTILIZING THE SAME | YEDA RESEARCH AND DEVELOPMENT COMPANY LTD. (IL) | 2006-08-17 | — | — | WO | claimed |
| EP-3228624-A2 | REDOX-ACTIVE CHROMOPHORE MOLECULES AND DEVICES UTILIZING THE SAME | YEDA RESEARCH AND DEVELOPMENT CO., LTD. (IL) | 2017-10-11 | — | — | EP | disclosed |
| US-9309274-B2 | Redox-active structures and devices utilizing the same | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2016-04-12 | — | — | US | disclosed |
| US-20150007371-A1 | REDOX-ACTIVE STRUCTURES AND DEVICES UTILIZING THE SAME | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2015-01-01 | — | — | US | disclosed |
| US-8865890-B2 | Redox-active structures and devices utilizing the same | YEDA RESEARCH AND DEVELOPMENT CO., LTD. (IL) | 2014-10-21 | — | — | US | disclosed |
| US-20140196180-A1 | REDOX-ACTIVE STRUCTURES AND DEVICES UTILIZING THE SAME | YEDA RESEARCH & DEVELOPMENT COMPANY LTD. (IL) | 2014-07-10 | — | — | US | disclosed |
| US-8722879-B2 | Redox-active structures and devices utilizing the same | YEDA RESEARCH & DEVELOPMENT COMPANY LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE (IL) | 2014-05-13 | — | — | US | disclosed |
| US-20110177964-A1 | CHEMOSENSORY ARRAYS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2011-07-21 | — | — | US | disclosed |
| EP-1854160-A2 | REDOX-ACTIVE STRUCTURES AND DEVICES UTILIZING THE SAME | YEDA RESEARCH AND DEVELOPMENT CO., LTD. (IL) | 2007-11-14 | — | — | EP | disclosed |
| US-20070258147-A1 | Redox-active structures and devices utilizing the same | YEDA RESEARCH & DEVELOPMENT CO., LTD. (IL) | 2007-11-08 | — | — | US | disclosed |
| WO-2006085319-A2 | REDOX-ACTIVE STRUCTURES AND DEVICES UTILIZING THE SAME | YEDA RESEARCH AND DEVELOPMENT COMPANY LTD. (IL) | 2006-08-17 | — | — | WO | disclosed |
| US-6610977-B2 | Security system for NBC-safe building | LOCKHEED MARTIN CORPORATION | 2003-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140196180-A1 | REDOX-ACTIVE STRUCTURES AND DEVICES UTILIZING THE SAME | GPX4, GPX1, LPO | TSHR 4361/4885TDP1 2760/4885ALDH1A1 233/4885 |
| US-20150007371-A1 | REDOX-ACTIVE STRUCTURES AND DEVICES UTILIZING THE SAME | GPX4, GPX1, LPO | TSHR 4361/4885TDP1 2760/4885ALDH1A1 233/4885 |
| US-20070258147-A1 | Redox-active structures and devices utilizing the same | GPX4, GPX1, LPO | TSHR 4361/4885TDP1 2760/4885ALDH1A1 233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.