Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2012848 | 0.88 | ALDH1A1 (0.55) | ALDH1A1TSHRHSD17B10ALOX15CA1 | |
| SCHEMBL2012846 | 0.88 | ALDH1A1 (0.55) | ALDH1A1TSHRHSD17B10ALOX15CA1 | |
| SCHEMBL7789704 | 0.82 | MEN1 (0.32) | TDP1LMNAKMT2AMEN1 | |
| SCHEMBL428216 | 0.77 | MEN1 (0.48) | ALDH1A1CA1CA2MAPTTDP1 | |
| SCHEMBL224555 | 0.76 | MAPT (0.55) | ALDH1A1TSHRMAPTTDP1MAPK1 | |
| SCHEMBL5537273 | 0.75 | TSHR (0.43) | ALDH1A1TSHRHSD17B10ALOX15CA1 | |
| SCHEMBL5536043 | 0.74 | MAPT (0.46) | ALDH1A1TSHRALOX15MAPTMAPK1 | |
| SCHEMBL9479616 | 0.74 | ALDH1A1 (0.65) | ALDH1A1TSHRHSD17B10ALOX15CA1 | |
| SCHEMBL222247 | 0.74 | ALDH1A1 (0.65) | ALDH1A1TSHRHSD17B10ALOX15CA1 | |
| SCHEMBL65261 | 0.72 | ALDH1A1 (1.00) | ALDH1A1TSHRHSD17B10ALOX15MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099157-A1 | TETRAHYDRO-PYRAZOLO-PYRIDINE THIOETHER MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | claimed |
| WO-2008100621-A2 | TETRAHYDRO-PYRAZOLO-PYRIDINE THIOETHER MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. (US) | 2008-08-21 | — | — | WO | claimed |
| EP-1189891-A1 | TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | LION Bioscience AG (DE) | 2002-03-27 | — | — | EP | claimed |
| US-6362342-B1 | BIOSYNTHESIS; DRUG LIBRARIES | LION BIOSCIENCE AG (DE) | 2002-03-26 | — | — | US | claimed |
| WO-2001000594-A1 | TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2001-01-04 | — | — | WO | claimed |
| US-4438136-A | INHIBITION OF THROMBOXANE ACTIVITY | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1984-03-20 | — | — | US | claimed |
| EP-0013608-B1 | SUBSTITUTED BICYCLO (2,2,1)HEPTANES AND HEPT-2-ENES AND THEIR PHARMACEUTICAL COMPOSITIONS | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1983-06-15 | — | — | EP | claimed |
| US-8637220-B2 | Actinic ray-sensitive or radiation-sensitive resin composition, and resist film and pattern forming method using the composition | FUJIFILM CORPORATION (JP) | 2014-01-28 | — | — | US | disclosed |
| US-20120107273-A1 | NEW PIPERAZINE COMPOUND AND USE THEREOF AS A HCV POLYMERASE INHIBITOR | JAPAN TOBACCO INC. (JP) | 2012-05-03 | — | — | US | disclosed |
| US-20120003583-A1 | ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE RESIN COMPOSITION, AND RESIST FILM AND PATTERN FORMING METHOD USING THE COMPOSITION | FUJIFILM CORPORATION (JP) | 2012-01-05 | — | — | US | disclosed |
| US-8017612-B2 | therapeutic agent for hepatitis C; R)-4-(4-trifluoromethyl-benzenesulfonyl)-piperazine-1,3-dicarboxylic acid 3-(4-isopropyl-benzylamide) 1-pyridin-4-ylamide; enzyme inhibitors | JAPAN TOBACCO INC. (JP) | 2011-09-13 | — | — | US | disclosed |
| US-20090099157-A1 | TETRAHYDRO-PYRAZOLO-PYRIDINE THIOETHER MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | disclosed |
| EP-2009004-A1 | NOVEL PIPERAZINE COMPOUND, AND USE THEREOF AS HCV POLYMERASE INHIBITOR | Japan Tobacco, Inc. (JP) | 2008-12-31 | — | — | EP | disclosed |
| EP-1048701-A1 | Delocalized cationic azo dye for ink jet ink | EASTMAN KODAK COMPANY (US) | 2000-11-02 | — | — | EP | disclosed |
| US-6136081-A | PRINTING WITH A DYE MIXTURE COMPRISING HUMECTANT AND A CO-MILLED COLOR MIXTURE OF PIGMENT YELLOW 74 AND AN ORGANIC PIGMENT WITH STRUCTURE SIMILAR TO THE PRIMARY DYE, RESULTING DISPERSION IS RESISTANT TO PARTICLE RIPENING | EASTMAN KODAK COMPANY (US) | 2000-10-24 | — | — | US | disclosed |
| US-6136080-A | A PHOTOSTABLE COLOR MIXTURE COMPRISING WATER, A HUMECTANT, AND A CATIONIC AZO DYE DERIVED FROM THE QUATERNIZATION OF A PYRAZOLEAZOINDOLE DYE | EASTMAN KODAK COMPANY (US) | 2000-10-24 | — | — | US | disclosed |
| US-6132501-A | AQUEOUS INK JET INK COMPRISING A HUMECTANT AND A COMILLED MIXTURE OF PIGMENT YELLOW 74(PY74) AND AN AZO-METHINE DYE OF GIVEN FORMULA WHICH PREVENTS RIPENING(INCREASE IN PARTICLE SIZE) OF PY74 | EASTMAN KODAK COMPANY (US) | 2000-10-17 | — | — | US | disclosed |
| EP-0540854-B1 | Preparation for promoting hair growth | SANSHO SEIYAKU KK (JP) | 1998-01-21 | — | — | EP | disclosed |
| US-5656264-A | ADMINISTERING TO THE SCALP OF THE MALE A PREPERATION CONSITING OF 6-BENZYLAMINOPURINE | SANSYO SEIYAKU CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |
| EP-0540854-A2 | Preparation for promoting hair growth | Sansho Seiyaku Co., Ltd. (JP) | 1993-05-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120107273-A1 | NEW PIPERAZINE COMPOUND AND USE THEREOF AS A HCV POLYMERASE INHIBITOR | POLR1C, POLR2E, POLR2H | ALDH1A1 557/4885TSHR 4735/4885HSD17B10 1248/4885 |
| US-20090099157-A1 | TETRAHYDRO-PYRAZOLO-PYRIDINE THIOETHER MODULATORS OF CATHEPSIN S | CTSS, CTSE, CTSK | ALDH1A1 4311/4885TSHR 1766/4885HSD17B10 3958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.