Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18725307 | 0.80 | HTR7 (0.34) | OPRM1OPRK1OPRD1 | |
| SCHEMBL4421968 | 0.76 | OPRM1 (0.36) | OPRM1OPRK1OPRL1OPRD1CYP2D6 | |
| SCHEMBL18284750 | 0.75 | OPRM1 (0.39) | OPRM1OPRK1OPRD1SLC6A4 | |
| SCHEMBL2732717 | 0.75 | HCAR2 (0.34) | OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL2452095 | 0.73 | SIGMAR1 (0.33) | OPRM1OPRK1NPC1SLC6A2SLC6A4 | |
| SCHEMBL20504486 | 0.71 | HSD17B10 (0.35) | CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8817763 | 0.71 | GNAI3 (0.35) | OPRM1OPRK1OPRL1OPRD1CYP2D6 | |
| SCHEMBL27587006 | 0.70 | SIGMAR1 (0.36) | OPRM1OPRD1CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL15094673 | 0.69 | APP (0.39) | OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL25181136 | 0.68 | GNAI3 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2544535-B1 | PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE AS INHIBITORS OF GLUCURONIDASE | NORTH CAROLINA CENTRAL UNIV (US) | 2017-04-19 | — | — | EP | claimed |
| US-20130345235-A1 | PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE AS INHIBITORS OF GLUCURONIDASE | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2013-12-26 | — | — | US | claimed |
| US-20130345196-A1 | PHENOXY THIOPHENE SULFONAMIDES AND OTHER COMPOUNDS FOR USE AS INHIBITORS OF BACTERIAL GLUCURONIDASE | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2013-12-26 | — | — | US | claimed |
| US-9617239-B2 | Phenoxy thiophene sulfonamides and their use as inhibitors of glucuronidase | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 2017-04-11 | — | — | US | disclosed |
| US-20130345196-A1 | PHENOXY THIOPHENE SULFONAMIDES AND OTHER COMPOUNDS FOR USE AS INHIBITORS OF BACTERIAL GLUCURONIDASE | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2013-12-26 | — | — | US | disclosed |
| US-20130345235-A1 | PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE AS INHIBITORS OF GLUCURONIDASE | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2013-12-26 | — | — | US | disclosed |
| WO-2011112858-A1 | PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE AS INHIBITORS OF GLUCURONIDASE | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 2011-09-15 | — | — | WO | disclosed |
| WO-2011084503-A1 | PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 2011-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130345235-A1 | PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE AS INHIBITORS OF GLUCURONIDASE | CES2, TOP1, GUSB | OPRM1 4217/4885OPRK1 3928/4885OPRL1 3103/4885 |
| US-20130345196-A1 | PHENOXY THIOPHENE SULFONAMIDES AND OTHER COMPOUNDS FOR USE AS INHIBITORS OF BACTERIAL GLUCURONIDASE | TOP2A, TOP1, TOP2B | OPRM1 3533/4885OPRK1 3132/4885OPRL1 1079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.