Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5865852 | 0.84 | TSHR (0.52) | TSHRALDH1A1PTPN1NR1H2NR1H3 | |
| SCHEMBL3378017 | 0.80 | TSHR (0.48) | TSHRALDH1A1PTPN1NR1H2NR1H3 | |
| SCHEMBL9644838 | 0.80 | NR1H3 (0.48) | TSHRALDH1A1PTPN1NR1H2NR1H3 | |
| SCHEMBL5377008 | 0.78 | NR1H2 (0.53) | TSHRALDH1A1PTPN1NR1H2NR1H3 | |
| SCHEMBL7173455 | 0.78 | CYP1A2 (0.48) | TSHRALDH1A1PTPN1CYP1A2CYP2C9 | |
| SCHEMBL36629 | 0.78 | CYP1A2 (0.48) | TSHRALDH1A1PTPN1CYP1A2CYP2C9 | |
| SCHEMBL21135302 | 0.76 | HSD11B1 (0.50) | TSHRALDH1A1PTPN1NR1H2NR1H3 | |
| SCHEMBL7743285 | 0.75 | CYP1A2 (0.46) | TSHRALDH1A1PTPN1CYP1A2CYP2C9 | |
| SCHEMBL30915210 | 0.75 | ALDH1A1 (0.70) | TSHRALDH1A1PTPN1NR1H2CYP3A4 | |
| SCHEMBL7766770 | 0.75 | ALDH1A1 (0.70) | TSHRALDH1A1PTPN1NR1H2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10450253-B2 | Preparation process of perfluoroalkyl compound with monohydroperfluoroalkane as starting material | KANTO DENKA KOGYO CO., LTD. (JP) | 2019-10-22 | — | — | US | disclosed |
| US-20190169107-A1 | PREPARATION PROCESS OF PERFLUOROALKYL COMPOUND WITH MONOHYDROPERFLUOROALKANE AS STARTING MATERIAL | NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY (JP) | 2019-06-06 | — | — | US | disclosed |
| US-8084617-B2 | Ionic liquids having fluoroalkyltrifluoroborate anions | MERCK PATENT GMBH (DE) | 2011-12-27 | — | — | US | disclosed |
| EP-2058319-B1 | Use of perfluoralkylphosphines as perfluoroalkylation reagents | MERCK PATENT GMBH (DE) | 2011-08-17 | — | — | EP | disclosed |
| EP-1730157-B1 | IONIC LIQUIDS COMPRISING FLUORALKYLTRIFFLUOROBORATE ANIONS | MERCK PATENT GMBH (DE) | 2011-07-27 | — | — | EP | disclosed |
| US-7632969-B2 | Process for the preparation of perfluoroalkylphosphines and the use thereof as perfluoroalkylating reagents | MERCK PATENT GMBH (DE) | 2009-12-15 | — | — | US | disclosed |
| EP-2058319-A1 | Method for manufacturing perfluoralkylphosphines and their application as perfluoralkylisation reagents | Merck Patent GmbH (DE) | 2009-05-13 | — | — | EP | disclosed |
| EP-1495037-B1 | METHOD FOR THE PRODUCTION OF PERFLUOROALKYL PHOSPHINES AND THE USE THEREOF AS PERFLUOROALKYLATING REACTANTS | MERCK PATENT GMBH (DE) | 2009-02-25 | — | — | EP | disclosed |
| US-20070213538-A1 | Ionic Liquids Having Fluoroalkyltrifluoroborate Anions | MERCK PATENT GMBH (DE) | 2007-09-13 | — | — | US | disclosed |
| US-20070191637-A1 | Reacting a (perfluoroalkyl)phosphorane fluoride with a hydride ion donor such as triethylsilane, tripropylsilane or sodium borohydride while refluxing | WELZ-BIERMANN URS | 2007-08-16 | — | — | US | disclosed |
| US-7208626-B2 | Method for the production of perfluoroalkyl phosphines and the use thereof as perfluoroalkylating reactants | MERCK PATENT GESELLSCHAFT (DE) | 2007-04-24 | — | — | US | disclosed |
| EP-1730157-A1 | IONIC LIQUIDS COMPRISING FLUORALKYLTRIFFLUOROBORATE ANIONS | MERCK PATENT GmbH (DE) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005105815-A1 | IONIC LIQUIDS COMPRISING FLUORALKYLTRIFFLUOROBORATE ANIONS | MERCK PATENT GMBH (DE) | 2005-11-10 | — | — | WO | disclosed |
| US-20050131256-A1 | Method for the production of perfluoroaldyl phosphines and the use thereof as perfluoroalkylating reactants | MERCK PATENT GMBH (DE) | 2005-06-16 | — | — | US | disclosed |
| US-20050119513-A1 | Method for perfluoroalkylation by means of tris (perfluoroalkyl) phosphine oxides | MERCK PATENT GMBH (DE) | 2005-06-02 | — | — | US | disclosed |
| EP-1495037-A1 | METHOD FOR THE PRODUCTION OF PERFLUOROALKYL PHOSPHINES AND THE USE THEREOF AS PERFLUOROALKYLATING REACTANTS | MERCK PATENT GmbH (DE) | 2005-01-12 | — | — | EP | disclosed |
| EP-1494982-A1 | METHOD FOR PERFLUOROALKYLATION BY MEANS OF TRIS(PERFLUOROALKYL)PHOSPHINE OXIDES | MERCK PATENT GmbH (DE) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003087020-A1 | METHOD FOR PERFLUOROALKYLATION BY MEANS OF TRIS(PERFLUOROALKYL)PHOSPHINE OXIDES | MERCK PATENT GMBH (DE) | 2003-10-23 | — | — | WO | disclosed |
| WO-2003087113-A1 | METHOD FOR THE PRODUCTION OF PERFLUOROALKYL PHOSPHINES AND THE USE THEREOF AS PERFLUOROALKYLATING REACTANTS | MERCK PATENT GMBH (DE) | 2003-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213538-A1 | Ionic Liquids Having Fluoroalkyltrifluoroborate Anions | AFF1, AFF2, AFF4 | TSHR 2063/4885ALDH1A1 1258/4885PTPN1 1354/4885 |
| US-20190169107-A1 | PREPARATION PROCESS OF PERFLUOROALKYL COMPOUND WITH MONOHYDROPERFLUOROALKANE AS STARTING MATERIAL | PFKFB1, PFKFB4, PFAS | TSHR 2116/4885ALDH1A1 505/4885PTPN1 3911/4885 |
| US-10450253-B2 | Preparation process of perfluoroalkyl compound with monohydroperfluoroalkane as starting material | PFKFB1, PFKFB4, PFAS | TSHR 2116/4885ALDH1A1 505/4885PTPN1 3911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.