SCHEMBL22320256

SCHEMBL22320256

O=Pc1ccc(-c2ccc3cccnc3n2)c(-c2cccc3ccccc23)c1-c1cccc2ccccc12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.40
KDM4E B2RXH2 5/20 0.40
HPGD P15428 4/20 0.40
MAPT P10636 3/20 0.40
HSD17B10 Q99714 2/20 0.40
GAA P10253 1/20 0.40
NPC1 O15118 2/20 0.36
TP53 P04637 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
MAPK1 P28482 1/20 0.36
TGFBR1 P36897 1/20 0.34
HTR2C P28335 3/20 0.33
CYP3A4 P08684 1/20 0.33
MEN1 O00255 1/20 0.33
LMNA P02545 1/20 0.33
KMT2A Q03164 1/20 0.33
DCTPP1 Q9H773 1/20 0.32
RAB9A P51151 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
DNMT1 P26358 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phosphine SCHEMBL22320255 0.81 KDM4E (0.41) ALDH1A1KDM4EHPGDMAPTHSD17B10
SCHEMBL30598386 0.80 KDM4E (0.53) ALDH1A1KDM4EHPGDMAPTHSD17B10
SCHEMBL27926146 0.74 ALDH1A1 (0.47) ALDH1A1KDM4EHPGDMAPTHSD17B10
SCHEMBL18394610 0.70 ALDH1A1 (0.46) ALDH1A1KDM4EHPGDMAPTHSD17B10
SCHEMBL29268839 0.69 ALDH1A1 (0.36) ALDH1A1KDM4EHPGDMAPTHSD17B10
SCHEMBL25766686 0.69 KDM4E (0.47) ALDH1A1KDM4EHPGDMAPTHSD17B10
SCHEMBL31612679 0.69 KDM4E (0.55) ALDH1A1KDM4EHPGDMAPTHSD17B10
SCHEMBL29129780 0.68 KDM4E (0.39) ALDH1A1KDM4EHPGDMAPTHSD17B10
SCHEMBL31139184 0.68 ALDH1A1 (0.36) ALDH1A1KDM4EHPGDMAPTHSD17B10
SCHEMBL21365377 0.68 KDM4E (0.52) ALDH1A1KDM4EHPGDMAPTHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4635960-A1 POLYCYCLIC AROMATIC COMPOUND Kyoto University (JP) 2025-10-22 EP disclosed
US-11877506-B2 Polycyclic aromatic compound KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2024-01-16 US disclosed
US-20230276708-A1 Polycyclic aromatic compound KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2023-08-31 US disclosed
US-11711970-B2 Organic electroluminescent device KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2023-07-25 US disclosed
US-20220077398-A1 POLYCYCLIC AROMATIC COMPOUND SK MATERIALS JNC CO., LTD. (KR) 2022-03-10 US disclosed
US-20220037591-A1 Polycyclic aromatic compound KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2022-02-03 US disclosed
US-20200259096-A1 ORGANIC ELECTROLUMINESCENT DEVICE KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2020-08-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11877506-B2 Polycyclic aromatic compound F11, C1R, RNF31 ALDH1A1 2814/4885KDM4E 4253/4885HPGD 1870/4885
US-20230276708-A1 Polycyclic aromatic compound ACVR1B, XDH, AHR ALDH1A1 2290/4885KDM4E 583/4885HPGD 1893/4885
US-20200259096-A1 ORGANIC ELECTROLUMINESCENT DEVICE LEF1, AOC2, AFF2 ALDH1A1 232/4885KDM4E 1417/4885HPGD 4024/4885
US-20220077398-A1 POLYCYCLIC AROMATIC COMPOUND ALOX12, LTB4R2, ALOX15 ALDH1A1 3342/4885KDM4E 2761/4885HPGD 414/4885
US-20220037591-A1 Polycyclic aromatic compound F11, C1R, RNF31 ALDH1A1 2814/4885KDM4E 4253/4885HPGD 1870/4885
US-11711970-B2 Organic electroluminescent device LEF1, AOC2, AFF2 ALDH1A1 232/4885KDM4E 1417/4885HPGD 4024/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.