Phosphine

Phosphine

SCHEMBL22320255

Oc1ccc(-c2ccc3cccnc3n2)c(-c2cccc3ccccc23)c1-c1cccc2ccccc12.P

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.41
ALDH1A1 P00352 4/20 0.41
HPGD P15428 4/20 0.41
MAPT P10636 4/20 0.41
HSD17B10 Q99714 2/20 0.41
GAA P10253 2/20 0.41
FTO Q9C0B1 2/20 0.38
KDM6B O15054 1/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
NPC1 O15118 2/20 0.38
TP53 P04637 1/20 0.38
MAPK1 P28482 1/20 0.38
PTPN22 Q9Y2R2 1/20 0.37
MIF P14174 1/20 0.37
TDP1 Q9NUW8 2/20 0.36
LMNA P02545 1/20 0.36
POLB P06746 1/20 0.36
HSP90AA1 P07900 1/20 0.36
ALOX12 P18054 1/20 0.36
OPRK1 P41145 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30598386 0.82 KDM4E (0.53) KDM4EALDH1A1HPGDMAPTHSD17B10
SCHEMBL22320256 0.81 ALDH1A1 (0.40) KDM4EALDH1A1HPGDMAPTHSD17B10
SCHEMBL1977339 0.76 PDE5A (0.50) KDM4EALDH1A1MAPTSMN1; SMN2TP53
SCHEMBL32677577 0.76 PDE5A (0.50) KDM4EALDH1A1MAPTSMN1; SMN2TP53
SCHEMBL27926146 0.76 ALDH1A1 (0.47) KDM4EALDH1A1HPGDMAPTHSD17B10
SCHEMBL3915265 0.74 CYP1A2 (0.48) KDM4EALDH1A1MAPTHSD17B10GAA
SCHEMBL30772437 0.74 CYP1A2 (0.56) KDM4EALDH1A1MAPTHSD17B10GAA
SCHEMBL18394610 0.71 ALDH1A1 (0.46) KDM4EALDH1A1HPGDMAPTHSD17B10
Hydrochloric Acid SCHEMBL29492626 0.71 NSD2 (0.51) KDM4EALDH1A1MAPTHSD17B10GAA
SCHEMBL29268839 0.71 ALDH1A1 (0.36) KDM4EALDH1A1HPGDMAPTHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4635960-A1 POLYCYCLIC AROMATIC COMPOUND Kyoto University (JP) 2025-10-22 EP disclosed
US-11877506-B2 Polycyclic aromatic compound KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2024-01-16 US disclosed
US-20230276708-A1 Polycyclic aromatic compound KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2023-08-31 US disclosed
US-11711970-B2 Organic electroluminescent device KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2023-07-25 US disclosed
US-20220077398-A1 POLYCYCLIC AROMATIC COMPOUND SK MATERIALS JNC CO., LTD. (KR) 2022-03-10 US disclosed
US-20220037591-A1 Polycyclic aromatic compound KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2022-02-03 US disclosed
US-20200259096-A1 ORGANIC ELECTROLUMINESCENT DEVICE KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2020-08-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11877506-B2 Polycyclic aromatic compound F11, C1R, RNF31 KDM4E 4253/4885ALDH1A1 2814/4885HPGD 1870/4885
US-20230276708-A1 Polycyclic aromatic compound ACVR1B, XDH, AHR KDM4E 583/4885ALDH1A1 2290/4885HPGD 1893/4885
US-20200259096-A1 ORGANIC ELECTROLUMINESCENT DEVICE LEF1, AOC2, AFF2 KDM4E 1417/4885ALDH1A1 232/4885HPGD 4024/4885
US-20220077398-A1 POLYCYCLIC AROMATIC COMPOUND ALOX12, LTB4R2, ALOX15 KDM4E 2761/4885ALDH1A1 3342/4885HPGD 414/4885
US-20220037591-A1 Polycyclic aromatic compound F11, C1R, RNF31 KDM4E 4253/4885ALDH1A1 2814/4885HPGD 1870/4885
US-11711970-B2 Organic electroluminescent device LEF1, AOC2, AFF2 KDM4E 1417/4885ALDH1A1 232/4885HPGD 4024/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.