Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | CES1 | P23141 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31400998 | 0.82 | MAOA (0.40) | MAPTCES1TDP1ALOX15SMN1; SMN2 | |
| SCHEMBL648422 | 0.77 | HDAC8 (0.54) | MAPTCES1TDP1ALOX15SMN1; SMN2 | |
| SCHEMBL10477310 | 0.75 | CES1 (0.43) | MAPTCES1TDP1ALOX15SMN1; SMN2 | |
| SCHEMBL11808646 | 0.75 | MAPT (0.43) | MAPTCES1TDP1ALOX15SMN1; SMN2 | |
| SCHEMBL4530513 | 0.75 | TSHR (0.45) | MAPTCES1TDP1ALOX15SMN1; SMN2 | |
| SCHEMBL554489 | 0.74 | ALOX15 (0.56) | MAPTCES1TDP1ALOX15SMN1; SMN2 | |
| SCHEMBL3427621 | 0.73 | KMT2A (0.55) | MAPTTDP1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL223551 | 0.72 | TDP1 (0.43) | MAPTCES1TDP1ALOX15SMN1; SMN2 | |
| SCHEMBL11359737 | 0.72 | MAPT (0.40) | MAPTCES1TDP1ALOX15SMN1; SMN2 | |
| SCHEMBL11883855 | 0.72 | AKT1 (0.47) | MAPTCES1TDP1ALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 217 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3268375-B1 | PHOTOCHROMIC THIENOCHROMENE COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2022-06-15 | — | — | EP | claimed |
| EP-3071576-B9 | PHOTOCHROMIC INDENO-FUSED RING PYRAN COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2021-12-22 | — | — | EP | claimed |
| EP-3645540-B1 | SILOLE AND GERMOLE FUSED RING PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL LTD (IE) | 2021-11-03 | — | — | EP | claimed |
| EP-3071576-B1 | PHOTOCHROMIC INDENO-FUSED RING PYRAN COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2021-08-18 | — | — | EP | claimed |
| CN-105199708-B | Photochromic compounds | 光学转变公司 | 2020-10-27 | — | — | CN | claimed |
| US-20200172798-A1 | Silole and Germole Fused Ring Photochromic Compounds | TRANSITIONS OPTICAL, LTD. (IE) | 2020-06-04 | — | — | US | claimed |
| EP-3645540-A1 | SILOLE AND GERMOLE FUSED RING PHOTOCHROMIC COMPOUNDS | Transitions Optical, Ltd. (IE) | 2020-05-06 | — | — | EP | claimed |
| EP-3621958-A1 | PHOTOCHROMIC INDENO FUSED PHENANTHRENOPYRAN COMPOUNDS | Transitions Optical, Ltd. (IE) | 2020-03-18 | — | — | EP | claimed |
| CN-110799514-A | Silole and germacyclopentadiene fused ring photochromic compounds | 光学转变有限公司 | 2020-02-14 | — | — | CN | claimed |
| US-20200048216-A1 | Photochromic Indeno Fused Phenanthrenopyran Compounds | TRANSITIONS OPTICAL, LTD. (IE) | 2020-02-13 | — | — | US | claimed |
| US-20110140056-A1 | Indeno-fused ring compounds | TRANSITIONS OPTICAL, INC. (US) | 2011-06-16 | — | — | US | claimed |
| US-20110135850-A1 | PHOTOALIGNMENT MATERIALS HAVING IMPROVED ADHESION | TRANSITIONS OPTICAL, INC. (US) | 2011-06-09 | — | — | US | claimed |
| US-20110128457-A1 | ALIGNMENT FACILITIES FOR OPTICAL DYES | TRANSITIONS OPTICAL, INC. (US) | 2011-06-02 | — | — | US | claimed |
| US-20110129678-A1 | Photochromic compounds and compositions | TRANSITIONS OPTICAL, INC. (US) | 2011-06-02 | — | — | US | claimed |
| WO-2010080311-A1 | CLEAR TO CIRCULAR POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME | TRANSITIONS OPTICAL, INC. (US) | 2010-07-15 | — | — | WO | claimed |
| WO-2010065406-A1 | ALIGNMENT FACILITIES FOR OPTICAL DYES | TRANSITIONS OPTICAL, INC. (US) | 2010-06-10 | — | — | WO | claimed |
| WO-2010065393-A1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2010-06-10 | — | — | WO | claimed |
| US-20090309076-A1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2009-12-17 | — | — | US | claimed |
| US-20090146104-A1 | ALIGNMENT FACILITIES FOR OPTICAL DYES | TRANSITIONS OPTICAL, INC. (US) | 2009-06-11 | — | — | US | claimed |
| US-20090135462-A1 | CLEAR TO CIRCULAR POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME | TRANSITIONS OPTICAL, INC. (US) | 2009-05-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048216-A1 | Photochromic Indeno Fused Phenanthrenopyran Compounds | ALDH1A2, RB1, INCENP | MAPT 1822/4885CES1 4274/4885TDP1 1453/4885 |
| US-20200172798-A1 | Silole and Germole Fused Ring Photochromic Compounds | CCNB2, SKP2, CCNB1 | MAPT 1701/4885CES1 4170/4885TDP1 4529/4885 |
| US-20110140056-A1 | Indeno-fused ring compounds | CRY2, SQOR, INTS6 | MAPT 2624/4885CES1 3698/4885TDP1 4435/4885 |
| US-20110129678-A1 | Photochromic compounds and compositions | CRY2, CRY1, PPOX | MAPT 573/4885CES1 3485/4885TDP1 995/4885 |
| US-20090309076-A1 | PHOTOCHROMIC COMPOUNDS | CCR4, CCR8, CBR3 | MAPT 3402/4885CES1 2138/4885TDP1 3195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.