SCHEMBL22471375

SCHEMBL22471375

CCn1c(=O)c2ncn(C)c2n(C)c1=O

nearest known ligand 0.51

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PDE4A P27815 6/20 0.49
ADORA2A P29274 6/20 0.49
PDE4B Q07343 6/20 0.49
PDE4C Q08493 6/20 0.49
PDE4D Q08499 6/20 0.49
ADORA2B P29275 8/20 0.45
LMNA P02545 1/20 0.43
BLM P54132 2/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
PMP22 Q01453 1/20 0.41
HSD17B10 Q99714 1/20 0.41
GLA P06280 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23473311 0.83 LMNA (0.40) PDE4AADORA2APDE4BPDE4CPDE4D
Isocaffiene SCHEMBL515995 0.80 LMNA (0.57) PDE4AADORA2APDE4BPDE4CPDE4D
SCHEMBL23974894 0.79 LMNA (0.38) PDE4AADORA2APDE4BPDE4CPDE4D
SCHEMBL23974900 0.79 ADORA3 (0.52) ADORA2BCYP3A4
SCHEMBL28973366 0.76 TNF (0.43) PDE4AADORA2APDE4BPDE4CPDE4D
SCHEMBL21534087 0.75 ADORA2B (0.43) PDE4AADORA2APDE4BPDE4CPDE4D
SCHEMBL19013753 0.74 SMN1; SMN2 (0.50) LMNACYP1A2CYP3A4
SCHEMBL516446 0.73 ADORA2A (0.74) PDE4AADORA2APDE4BPDE4CPDE4D
SCHEMBL15086862 0.73 LMNA (0.40) PDE4AADORA2APDE4BPDE4CPDE4D
SCHEMBL13111707 0.73 PDE1A (0.49) PDE4AADORA2APDE4BPDE4CPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260083743-A1 NUCLEOSIDE DERIVATIVE FOR PREVENTING AND TREATING INFLAMMATION AND APPLICATION THEREOF WEST CHINA HOSPITAL OF SICHUAN UNIVERSITY (CN) 2026-03-26 US disclosed
US-20220288084-A1 NUCLEOSIDE DERIVATIVE FOR PREVENTING AND TREATING INFLAMMATION AND APPLICATION THEREOF WEST CHINA HOSPITAL OF SICHUAN UNIVERSITY (CN) 2022-09-15 US disclosed
CN-109912598-B Nucleoside derivative for preventing and treating inflammatory reaction and application thereof 四川大学华西医院 2022-09-13 CN disclosed
EP-3950689-A1 NUCLEOSIDE DERIVATIVE FOR PREVENTING AND TREATING INFLAMMATION AND APPLICATION THEREOF West China Hospital of Sichuan University (CN) 2022-02-09 EP disclosed
WO-2020192665-A1 NUCLEOSIDE DERIVATIVE FOR PREVENTING AND TREATING INFLAMMATION AND APPLICATION THEREOF 四川大学华西医院 2020-10-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260083743-A1 NUCLEOSIDE DERIVATIVE FOR PREVENTING AND TREATING INFLAMMATION AND APPLICATION THEREOF SLC5A1, PC, LDHA PDE4A 2742/4885ADORA2A 314/4885PDE4B 2990/4885
US-20220288084-A1 NUCLEOSIDE DERIVATIVE FOR PREVENTING AND TREATING INFLAMMATION AND APPLICATION THEREOF PNP, HMGB3, ADAR PDE4A 348/4885ADORA2A 29/4885PDE4B 289/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.