SCHEMBL22497570

SCHEMBL22497570

COCCOC(=O)c1cn(C2CC2)c2ccc(Cl)cc2c1=O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAPDH P04406 1/20 0.45
MAPK8 P45983 1/20 0.41
MAPK9 P45984 1/20 0.41
MAPK10 P53779 1/20 0.41
ALDH1A1 P00352 2/20 0.41
TSHR P16473 2/20 0.41
KDM4E B2RXH2 2/20 0.41
HPGD P15428 2/20 0.41
ALOX15 P16050 1/20 0.41
CASP1 P29466 1/20 0.41
HSD17B10 Q99714 1/20 0.41
PIK3CD O00329 1/20 0.40
PIK3R1 P27986 1/20 0.40
PIK3CA P42336 1/20 0.40
PIK3CG P48736 1/20 0.40
CNR2 P34972 3/20 0.39
LMNA P02545 1/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
PTGDR2 Q9Y5Y4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22506770 0.89 GAPDH (0.45) GAPDHALDH1A1TSHRKDM4EHPGD
SCHEMBL22497629 0.87 HTR3A (0.45) ALDH1A1TSHRKDM4EHPGDCASP1
SCHEMBL22506776 0.83 ALDH1A1 (0.46) ALDH1A1KDM4EHPGDHSD17B10PIK3CD
SCHEMBL28440261 0.83 KDM4E (0.49) ALDH1A1KDM4EHPGDHSD17B10PIK3CD
SCHEMBL24137227 0.81 CNR1 (0.44) MAPK8ALDH1A1TSHRKDM4EHPGD
SCHEMBL22506780 0.81 CNR2 (0.45) ALDH1A1TSHRKDM4EHPGDCASP1
SCHEMBL22506783 0.79 KDM4E (0.46) ALDH1A1KDM4EHPGDALOX15HSD17B10
SCHEMBL30906942 0.79 P2RX3 (0.49) GAPDHALDH1A1TSHRKDM4EHPGD
SCHEMBL3815694 0.79 P2RX3 (0.49) GAPDHALDH1A1TSHRKDM4EHPGD
SCHEMBL22506564 0.79 PIK3CG (0.46) GAPDHALDH1A1KDM4EHPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3929180-B1 QUINOLINE CARBOXYLIC ACID ESTER COMPOUND AND PREPARATION METHOD AND USE THEREOF SHANDONG UNITED PESTICIDE IND CO LTD (CN) 2026-03-04 EP disclosed
US-20250313533-A1 QUINOLINE CARBOXYLIC ACID ESTER COMPOUND AND PREPARATION METHOD AND USE THEREOF SHANDONG UNITED PESTICIDE INDUSTRY CO., LTD. (CN) 2025-10-09 US disclosed
US-20220220076-A1 QUINOLINE CARBOXYLATE COMPOUND AND PREPARATION METHOD AND USE THEREOF SHANDONG UNITED PESTICIDE INDUSTRY CO., LTD. (CN) 2022-07-14 US disclosed
US-20220220076-A1 QUINOLINE CARBOXYLATE COMPOUND AND PREPARATION METHOD AND USE THEREOF SHANDONG UNITED PESTICIDE INDUSTRY CO., LTD. (CN) 2022-07-14 US disclosed
EP-3929180-A1 QUINOLINE CARBOXYLIC ACID ESTER COMPOUND AND PREPARATION METHOD AND USE THEREOF Shandong United Pesticide Industry Co., Ltd. (CN) 2021-12-29 EP disclosed
EP-3929180-A1 QUINOLINE CARBOXYLIC ACID ESTER COMPOUND AND PREPARATION METHOD AND USE THEREOF Shandong United Pesticide Industry Co., Ltd. (CN) 2021-12-29 EP disclosed
WO-2020199981-A1 QUINOLINE CARBOXYLIC ACID ESTER COMPOUND AND PREPARATION METHOD AND USE THEREOF 山东省联合农药工业有限公司 2020-10-08 WO disclosed
WO-2020199981-A1 QUINOLINE CARBOXYLIC ACID ESTER COMPOUND AND PREPARATION METHOD AND USE THEREOF 山东省联合农药工业有限公司 2020-10-08 WO disclosed
CN-110066245-B Quinoline carboxylic ester compound and preparation method and application thereof 山东省联合农药工业有限公司 2020-09-22 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250313533-A1 QUINOLINE CARBOXYLIC ACID ESTER COMPOUND AND PREPARATION METHOD AND USE THEREOF NAAA, SDHA, GLUL GAPDH 171/4885MAPK8 3476/4885MAPK9 2304/4885
US-20220220076-A1 QUINOLINE CARBOXYLATE COMPOUND AND PREPARATION METHOD AND USE THEREOF SDHA, GLUL, PGLS GAPDH 194/4885MAPK8 3874/4885MAPK9 3155/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.