SCHEMBL22605364

SCHEMBL22605364

CC(C)n1ccc(N(C)C)nc1=O

nearest known ligand 0.38

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SMPD3 Q9NY59 2/20 0.38
CRHR1 P34998 2/20 0.36
NCF1 P14598 1/20 0.32
TSHR P16473 1/20 0.32
KDM5A P29375 1/20 0.32
MAP4K1 Q92918 2/20 0.31
DYRK1A Q13627 1/20 0.31
LCP2 Q13094 1/20 0.31
CYP1A2 P05177 1/20 0.30
CYP2C19 P33261 1/20 0.30
HTT P42858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12942479 0.79 KDM5A (0.33) KDM5A
SCHEMBL25915911 0.77 SMPD3 (0.33) SMPD3
SCHEMBL15360079 0.75 SMPD3 (0.44) SMPD3CRHR1NCF1DYRK1ACYP1A2
SCHEMBL15032488 0.73 KDM5A (0.35) KDM5A
SCHEMBL10643795 0.73 KDM5A (0.33) KDM5ADYRK1A
SCHEMBL24879570 0.73 SMPD3 (0.40) SMPD3CRHR1NCF1
SCHEMBL784164 0.73 ADORA2A (0.36) KDM5ADYRK1A
SCHEMBL24896141 0.73 SMPD3 (0.42) SMPD3CRHR1NCF1
SCHEMBL11323732 0.73 KDM5A (0.35) KDM5A
SCHEMBL15948779 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240240182-A1 HUMAN CHROMOSOME 9 OPEN READING FRAME 72 (C9ORF72) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF BANK OF AMERICA, N.A. 2024-07-18 US disclosed
US-20240209339-A1 REDIRECTING RISC FOR RNA EDITING ALNYLAM PHARMACEUTICALS, INC. (US) 2024-06-27 US disclosed
US-20240209339-A1 REDIRECTING RISC FOR RNA EDITING ALNYLAM PHARMACEUTICALS, INC. (US) 2024-06-27 US disclosed
US-20240209373-A1 ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 1 (ELOVL1) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF ALNYLAM PHARMACEUTICALS, INC. (US) 2024-06-27 US disclosed
US-20240209374-A1 iRNA COMPOSITIONS AND METHODS FOR SILENCING CHITINASE 3-LIKE PROTEIN 1/YKL-40 (CHI3L1/YKL-40) PROTEIN ALNYLAM PHARMACEUTICALS, INC. (US) 2024-06-27 US disclosed
US-20240067972-A1 DIPEPTIDYL PEPTIDASE 4 (DPP4) IRNA COMPOSITIONS AND METHODS OF USE THEREOF BANK OF AMERICA, N.A. 2024-02-29 US disclosed
US-20240067972-A1 DIPEPTIDYL PEPTIDASE 4 (DPP4) IRNA COMPOSITIONS AND METHODS OF USE THEREOF BANK OF AMERICA, N.A. 2024-02-29 US disclosed
WO-2023192977-A2 SNCA-TARGETING SIRNA COMPOSITIONS FOR TREATING SNCA-ASSOCIATED DISEASE ALNYLAM PHARMACEUTICALS, INC. (US) 2023-10-05 WO disclosed
US-20230287424-A1 RNAi COMPOSITIONS AND METHODS OF USE THEREOF FOR DELIVERY BY INHALATION BANK OF AMERICA, N.A. 2023-09-14 US disclosed
US-20230272382-A1 COMPLEMENT COMPONENT C3 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING COMPLEMENT COMPONENT C3-ASSOCIATED DISEASES BANK OF AMERICA, N.A. 2023-08-31 US disclosed
WO-2022066847-A1 DIPEPTIDYL PEPTIDASE 4 (DPP4) IRNA COMPOSITIONS AND METHODS OF USE THEREOF ALNYLAM PHARMACEUTICALS, INC. (US) 2022-03-31 WO disclosed
WO-2021252557-A1 RNAI COMPOSITIONS AND METHODS OF USE THEREOF FOR DELIVERY BY INHALATION ALNYLAM PHARMACEUTICALS, INC. (US) 2021-12-16 WO disclosed
WO-2021202443-A2 COMPOSITIONS AND METHODS FOR SILENCING DNAJC15 GENE EXPRESSION ALNYLAM PHARMACEUCTICALS, INC. (US) 2021-10-07 WO disclosed
WO-2021202511-A2 MICROTUBULE ASSOCIATED PROTEIN TAU (MAPT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF ALNYLAM PHARMACEUTICALS, INC. (US) 2021-10-07 WO disclosed
WO-2021195307-A1 CORONAVIRUS IRNA COMPOSITIONS AND METHODS OF USE THEREOF ALNYLAM PHARMACEUTICALS, INC. (US) 2021-09-30 WO disclosed
US-20210238594-A1 COMPOSITIONS AND METHODS FOR IMPROVING STRAND BIASED ALNYLAM PHARMACEUTICALS, INC. (US) 2021-08-05 US disclosed
WO-2021119226-A1 HUMAN CHROMOSOME 9 OPEN READING FRAME 72 (C9ORF72) IRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF ALNYLAM PHARMACEUTICALS, INC. (US) 2021-06-17 WO disclosed
US-11034957-B2 Amyloid precursor protein (APP) RNAi agent compositions and methods of use thereof ALNYLAM PHARMACEUTICALS, INC. (US) 2021-06-15 US disclosed
WO-2021087036-A1 HUNTINGTIN (HTT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF ALNYLAM PHARMACEUTICALS, INC. (US) 2021-05-06 WO disclosed
US-20200339991-A1 AMYLOID PRECURSOR PROTEIN (APP) RNAi AGENT COMPOSITIONS AND METHODS OF USE THEREOF ALNYLAM PHARMACEUTICALS, INC. (US) 2020-10-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230287424-A1 RNAi COMPOSITIONS AND METHODS OF USE THEREOF FOR DELIVERY BY INHALATION MTREX, RNASEH1, RNASE1 SMPD3 371/4885CRHR1 2877/4885NCF1 1358/4885
US-20200339991-A1 AMYLOID PRECURSOR PROTEIN (APP) RNAi AGENT COMPOSITIONS AND METHODS OF USE THEREOF APP, APBA1, PSEN1 SMPD3 152/4885CRHR1 4404/4885NCF1 1486/4885
US-20240067972-A1 DIPEPTIDYL PEPTIDASE 4 (DPP4) IRNA COMPOSITIONS AND METHODS OF USE THEREOF DPP4, DPP3, DPP7 SMPD3 372/4885CRHR1 3262/4885NCF1 4005/4885
US-11034957-B2 Amyloid precursor protein (APP) RNAi agent compositions and methods of use thereof APP, APBA1, PSEN1 SMPD3 152/4885CRHR1 4404/4885NCF1 1486/4885
US-20240209339-A1 REDIRECTING RISC FOR RNA EDITING ADAR, AGO2, METTL16 SMPD3 1117/4885CRHR1 4012/4885NCF1 4319/4885
US-20240209374-A1 iRNA COMPOSITIONS AND METHODS FOR SILENCING CHITINASE 3-LIKE PROTEIN 1/YKL-40 (CHI3L1/YKL-40) PROTEIN CHI3L1, CHIA, CHI3L2 SMPD3 190/4885CRHR1 2971/4885NCF1 1233/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.