Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.33 |
| ▸ | MTOR | P42345 | 6/20 | 0.33 |
| ▸ | GCKR | Q14397 | 2/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29462389 | 1.00 | ALOX5AP (0.37) | ALOX5APFEN1AKR1C3CHRNB2CHRNA4 | |
| SCHEMBL22650562 | 0.86 | PIK3CA (0.35) | AKR1C3CHRNB2CHRNA4PIK3CAMTOR | |
| SCHEMBL22650910 | 0.85 | DRD3 (0.35) | AKR1C3PIK3CAMTOR | |
| SCHEMBL22650566 | 0.84 | DPP4 (0.33) | ALOX5APFEN1AKR1C3CHRNB2CHRNA4 | |
| SCHEMBL29491165 | 0.81 | SPR (0.38) | PIK3CA | |
| SCHEMBL22650412 | 0.81 | SPR (0.38) | PIK3CA | |
| SCHEMBL22650565 | 0.81 | DDB1 (0.38) | AKR1C3L3MBTL3DDB1CRBN | |
| SCHEMBL22650730 | 0.79 | ALOX5AP (0.40) | ALOX5APFEN1AKR1C3CHRNB2CHRNA4 | |
| SCHEMBL1992323 | 0.79 | CDK2 (0.43) | IRAK4PTPN11MAP4K4 | |
| SCHEMBL22650589 | 0.78 | CHRNB2 (0.36) | ALOX5APFEN1AKR1C3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4146647-B1 | CDK INHIBITORS | GENENTECH INC (US) | 2026-04-15 | — | — | EP | disclosed |
| US-20250325544-A1 | CDK INHIBITORS | GENENTECH, INC. (US) | 2025-10-23 | — | — | US | disclosed |
| US-20250281487-A1 | CDK INHIBITORS | GENENTECH, INC. (US) | 2025-09-11 | — | — | US | disclosed |
| US-20250275971-A1 | CDK INHIBITORS | GENENTECH, INC. (US) | 2025-09-04 | — | — | US | disclosed |
| US-20250275972-A1 | CDK INHIBITORS | GENENTECH, INC. (US) | 2025-09-04 | — | — | US | disclosed |
| US-12285429-B2 | CDK inhibitors | GENENTECH, INC. (US) | 2025-04-29 | — | — | US | disclosed |
| US-20250064806-A1 | CDK INHIBITORS | GENENTECH, INC. | 2025-02-27 | — | — | US | disclosed |
| US-20240066031-A1 | CDK INHIBITORS | GENENTECH, INC. | 2024-02-29 | — | — | US | disclosed |
| US-20240066031-A1 | CDK INHIBITORS | GENENTECH, INC. | 2024-02-29 | — | — | US | disclosed |
| US-20240066031-A1 | CDK INHIBITORS | GENENTECH, INC. | 2024-02-29 | — | — | US | disclosed |
| CN-115803327-B | CDK inhibitors | 锐格医药有限公司 | 2024-02-13 | — | — | CN | disclosed |
| US-20240033264-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2024-02-01 | — | — | US | disclosed |
| US-20230174512-A1 | CDK INHIBITORS | GENENTECH, INC. | 2023-06-08 | — | — | US | disclosed |
| US-20230174512-A1 | CDK INHIBITORS | GENENTECH, INC. | 2023-06-08 | — | — | US | disclosed |
| US-20230174512-A1 | CDK INHIBITORS | GENENTECH, INC. | 2023-06-08 | — | — | US | disclosed |
| CN-115803327-A | CDK inhibitors | 上海齐鲁锐格医药研发有限公司 | 2023-03-14 | — | — | CN | disclosed |
| US-20220296595-A1 | CDK INHIBITORS | GENENTECH, INC. | 2022-09-22 | — | — | US | disclosed |
| CN-114364675-A | CDK inhibitors | 上海齐鲁锐格医药研发有限公司 | 2022-04-15 | — | — | CN | disclosed |
| WO-2021226140-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2021-11-11 | — | — | WO | disclosed |
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250281487-A1 | CDK INHIBITORS | CDK6, CDK9, CDKL1 | ALOX5AP 3983/4885FEN1 1196/4885AKR1C3 2678/4885 |
| US-20240033264-A1 | CDK INHIBITORS | CDK9, CDKL1, CDK3 | ALOX5AP 3896/4885FEN1 1089/4885AKR1C3 2710/4885 |
| US-20240066031-A1 | CDK INHIBITORS | CDK9, CDKL1, CDK3 | ALOX5AP 3896/4885FEN1 1089/4885AKR1C3 2710/4885 |
| US-20250064806-A1 | CDK INHIBITORS | CDK9, CDK6, CDK3 | ALOX5AP 3609/4885FEN1 1337/4885AKR1C3 2742/4885 |
| US-12285429-B2 | CDK inhibitors | CDK9, CDK3, CDKL1 | ALOX5AP 3516/4885FEN1 1080/4885AKR1C3 2703/4885 |
| US-20250325544-A1 | CDK INHIBITORS | CDK6, CDK9, CDKL1 | ALOX5AP 3983/4885FEN1 1196/4885AKR1C3 2678/4885 |
| US-20250275972-A1 | CDK INHIBITORS | CDK9, CDK6, CDK3 | ALOX5AP 3609/4885FEN1 1337/4885AKR1C3 2742/4885 |
| US-20220296595-A1 | CDK INHIBITORS | CDKL1, CDK9, CDK6 | ALOX5AP 4105/4885FEN1 934/4885AKR1C3 3618/4885 |
| US-20230174512-A1 | CDK INHIBITORS | CDK9, CDKL1, CDK3 | ALOX5AP 3896/4885FEN1 1089/4885AKR1C3 2710/4885 |
| US-20250275971-A1 | CDK INHIBITORS | CDK6, CDK9, CDKL1 | ALOX5AP 3983/4885FEN1 1196/4885AKR1C3 2678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.