SCHEMBL2267916

SCHEMBL2267916

CC(C)(C)OC(=O)c1ccc(Oc2ccc(F)cc2F)cc1NC(=O)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PYGM P11217 4/20 0.46
PYGL P06737 3/20 0.46
LMNA P02545 3/20 0.45
SMN1; SMN2 Q16637 3/20 0.45
L3MBTL1 Q9Y468 2/20 0.45
NPC1 O15118 2/20 0.45
RAB9A P51151 2/20 0.45
GAA P10253 1/20 0.45
HDAC1 Q13547 1/20 0.45
KDM4E B2RXH2 2/20 0.44
MAPT P10636 1/20 0.44
CYP1A2 P05177 1/20 0.43
CYP2D6 P10635 1/20 0.43
TSHR P16473 1/20 0.43
CYP2C19 P33261 1/20 0.43
MAPK1 P28482 1/20 0.42
HSD17B10 Q99714 1/20 0.42
PNLIP P16233 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2269721 0.86 PYGM (0.58) PYGMPYGLLMNASMN1; SMN2L3MBTL1
SCHEMBL2277873 0.85 PYGM (0.44) PYGMPYGLLMNASMN1; SMN2HDAC1
SCHEMBL2270537 0.82 PNLIP (0.54) PYGMPYGLLMNASMN1; SMN2L3MBTL1
SCHEMBL2269139 0.81 CYP2C9 (0.47) PYGMPYGLSMN1; SMN2NPC1RAB9A
SCHEMBL14428492 0.80 SMN1; SMN2 (0.49) PYGMPYGLLMNASMN1; SMN2L3MBTL1
SCHEMBL2274026 0.79 PGR (0.61) PYGMSMN1; SMN2NPC1RAB9AKDM4E
SCHEMBL2271217 0.78 PYGM (0.61) PYGMPYGLL3MBTL1MAPT
SCHEMBL2269635 0.78 PYGM (0.56) PYGMPYGLLMNASMN1; SMN2L3MBTL1
SCHEMBL2269667 0.78 F10 (0.53) PYGMGAAHDAC1KDM4EMAPT
SCHEMBL2276220 0.78 L3MBTL1 (0.55) LMNASMN1; SMN2L3MBTL1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 PYGM 1299/4885PYGL 1834/4885LMNA 3235/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.