SCHEMBL2270537

SCHEMBL2270537

CC(C)(C)OC(=O)c1ccc(Oc2ccc(Cl)cc2Cl)cc1NC(=O)c1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PNLIP P16233 4/20 0.54
PYGL P06737 2/20 0.49
PYGM P11217 2/20 0.49
MRGPRX4 Q96LA9 1/20 0.48
KMT2A Q03164 3/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
LMNA P02545 2/20 0.47
MEN1 O00255 2/20 0.47
NPSR1 Q6W5P4 2/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
PKM P14618 1/20 0.47
SERPINE1 P05121 1/20 0.47
TDP1 Q9NUW8 1/20 0.46
MAPT P10636 1/20 0.44
ALDH1A1 P00352 2/20 0.43
NPC1 O15118 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2270281 0.86 PNLIP (0.62) PNLIPPYGLPYGMMRGPRX4KMT2A
SCHEMBL2267916 0.82 PYGM (0.46) PNLIPPYGLPYGMSMN1; SMN2LMNA
SCHEMBL2269139 0.81 CYP2C9 (0.47) PYGLPYGMKMT2ASMN1; SMN2MEN1
SCHEMBL14428240 0.80 PNLIP (0.60) PNLIPPYGLPYGMMRGPRX4KMT2A
SCHEMBL2274026 0.79 PGR (0.61) PYGMKMT2ASMN1; SMN2MEN1MAPT
SCHEMBL2277873 0.79 PYGM (0.44) PYGLPYGMKMT2ASMN1; SMN2LMNA
SCHEMBL2275605 0.78 ACLY (0.53) KMT2ASMN1; SMN2MEN1NPSR1SERPINE1
SCHEMBL2269667 0.78 F10 (0.53) PYGMKMT2AMEN1NPSR1PKM
SCHEMBL5145423 0.78 PYGM (0.61) PNLIPPYGLPYGMKMT2ASMN1; SMN2
SCHEMBL2275398 0.78 SMN1; SMN2 (0.54) PYGLPYGMKMT2ASMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 PNLIP 4862/4885PYGL 1834/4885PYGM 1299/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.