SCHEMBL2268313

SCHEMBL2268313

O=C(Nc1cc(CCc2ccccc2)ccc1C(=O)O)c1ccnc(-n2cccc2)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM5A P29375 4/20 0.47
KDM5B Q9UGL1 4/20 0.47
KDM4C Q9H3R0 3/20 0.47
KDM4A O75164 1/20 0.47
CA12 O43570 2/20 0.43
CA1 P00915 2/20 0.43
CA4 P22748 2/20 0.43
CA7 P43166 2/20 0.43
STING1 Q86WV6 1/20 0.43
KDM4E B2RXH2 1/20 0.42
KDM5C P41229 1/20 0.42
LRRK2 Q5S007 1/20 0.41
MEN1 O00255 1/20 0.41
PKM P14618 1/20 0.41
KMT2A Q03164 1/20 0.41
PLK1 P53350 6/20 0.41
PLK3 Q9H4B4 4/20 0.41
LTC4S Q16873 1/20 0.40
MCL1 Q07820 1/20 0.40
BCL2A1 Q16548 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2276256 0.85 SIRT2 (0.45) CA12CA1CA4CA7STING1
SCHEMBL2270566 0.84 ACLY (0.56) STING1MEN1PKMKMT2A
SCHEMBL2270071 0.81 SERPINE1 (0.46) STING1
SCHEMBL2275929 0.79 KMT2A (0.62) KDM4CCA12CA1CA4CA7
SCHEMBL2270812 0.79 ALDH1A1 (0.47) KDM4CCA12CA1CA4CA7
SCHEMBL14428225 0.78 SIRT2 (0.44) STING1KDM4E
SCHEMBL2268181 0.76 MAPT (0.52) KDM4EMEN1KMT2A
SCHEMBL28767708 0.76 LMNA (0.57) KDM4ELRRK2MEN1KMT2A
SCHEMBL2272111 0.75 SUCNR1 (0.59) MEN1PKMKMT2ALTC4SMCL1
SCHEMBL2270925 0.75 PLK1 (0.57) CA12CA1CA4CA7MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 KDM5A 793/4885KDM5B 896/4885KDM4C 1397/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.