SCHEMBL2270566

SCHEMBL2270566

O=C(Nc1cc(-c2ccccc2)ccc1C(=O)O)c1ccnc(-n2cccc2)c1

nearest known ligand 0.56

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ACLY P53396 6/20 0.56
SUCNR1 Q9BXA5 1/20 0.48
HDAC1 Q13547 6/20 0.48
DHODH Q02127 1/20 0.48
STING1 Q86WV6 1/20 0.45
HDAC2 Q92769 3/20 0.44
SERPINE1 P05121 2/20 0.44
HDAC3 O15379 2/20 0.43
MEN1 O00255 1/20 0.43
PKM P14618 1/20 0.43
KMT2A Q03164 1/20 0.43
GSK3B P49841 1/20 0.43
PRSS12 P56730 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2269782 0.84 ACLY (0.56) ACLYSUCNR1HDAC1DHODHSTING1
SCHEMBL2270071 0.84 SERPINE1 (0.46) STING1SERPINE1PRSS12
SCHEMBL2268313 0.84 KDM5A (0.47) STING1MEN1PKMKMT2A
SCHEMBL1316866 0.82 ACLY (0.62) ACLYSUCNR1HDAC1DHODHHDAC2
SCHEMBL2269037 0.81 ACLY (0.59) ACLYSUCNR1HDAC1DHODHHDAC2
SCHEMBL2272006 0.80 ACLY (0.62) ACLYSUCNR1HDAC1DHODHHDAC2
SCHEMBL2272853 0.79 ACLY (0.60) ACLYSUCNR1HDAC1DHODHHDAC2
SCHEMBL28767708 0.78 LMNA (0.57) HDAC1HDAC2MEN1KMT2A
SCHEMBL2275720 0.78 SUCNR1 (0.73) ACLYSUCNR1HDAC1DHODHHDAC2
SCHEMBL2274895 0.78 ACLY (0.56) ACLYSUCNR1HDAC1DHODHHDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 ACLY 653/4885SUCNR1 637/4885HDAC1 71/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.