SCHEMBL2270071

SCHEMBL2270071

O=C(Nc1cc(Oc2ccccc2)ccc1C(=O)O)c1ccnc(-n2cccc2)c1

nearest known ligand 0.53

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SERPINE1 P05121 1/20 0.46
PRSS12 P56730 3/20 0.44
PYGM P11217 2/20 0.43
STING1 Q86WV6 1/20 0.43
PYGL P06737 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2270356 0.85 SERPINE1 (0.48) SERPINE1PRSS12
SCHEMBL2270566 0.84 ACLY (0.56) SERPINE1PRSS12STING1
SCHEMBL2271446 0.82 PYGM (0.50) SERPINE1PRSS12PYGMPYGL
SCHEMBL2275558 0.81 SERPINE1 (0.58) SERPINE1PRSS12PYGMPYGL
SCHEMBL2268313 0.81 KDM5A (0.47) STING1
SCHEMBL2270854 0.80 PYGL (0.44) SERPINE1PYGMPYGL
SCHEMBL2271588 0.79 SERPINE1 (0.64) SERPINE1PYGMPYGL
SCHEMBL2274764 0.79 ALDH1A1 (0.47) SERPINE1PRSS12PYGMPYGL
SCHEMBL2273868 0.76 NPC1 (0.57) SERPINE1PRSS12
SCHEMBL2273063 0.76 KAT6A (0.50) SERPINE1PRSS12PYGMPYGL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 SERPINE1 101/4885PRSS12 1133/4885PYGM 1299/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.