SCHEMBL2270119

SCHEMBL2270119

O=C(Nc1cc(Oc2ccccc2)ccc1C(=O)O)c1ccc(Cl)cc1Cl

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 3/20 0.64
SERPINE1 P05121 1/20 0.62
STK39 Q9UEW8 3/20 0.59
PPARA Q07869 1/20 0.55
MEN1 O00255 2/20 0.54
KMT2A Q03164 2/20 0.54
NPSR1 Q6W5P4 2/20 0.54
PKM P14618 1/20 0.54
GRIK1 P39086 3/20 0.52
KDM4E B2RXH2 1/20 0.51
NPC1 O15118 1/20 0.51
GAA P10253 1/20 0.51
MAPT P10636 1/20 0.51
RAB9A P51151 1/20 0.51
LMNA P02545 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
PYGL P06737 1/20 0.50
PYGM P11217 1/20 0.50
ACLY P53396 1/20 0.50
TP53 P04637 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2269563 0.90 STK39 (0.57) PPARGSERPINE1STK39MEN1KMT2A
SCHEMBL2272043 0.86 SERPINE1 (0.75) SERPINE1MEN1KMT2ANPSR1PKM
SCHEMBL7035705 0.86 SERPINE1 (0.67) PPARGSERPINE1STK39PPARANPSR1
SCHEMBL2272347 0.85 SERPINE1 (0.69) SERPINE1MEN1KMT2ANPSR1PKM
SCHEMBL2270287 0.84 PYGM (0.70) SERPINE1MEN1KMT2ANPSR1PKM
SCHEMBL1308769 0.84 PPARG (0.69) PPARGPPARAMEN1KMT2ANPSR1
SCHEMBL2275201 0.84 ACLY (0.67) SERPINE1STK39MEN1KMT2ANPSR1
SCHEMBL2275857 0.84 SERPINE1 (0.54) SERPINE1STK39MEN1KMT2APYGL
SCHEMBL2891026 0.83 PPARG (0.68) PPARGPPARAMEN1KMT2APKM
SCHEMBL2274838 0.82 SERPINE1 (0.66) SERPINE1MEN1KMT2ANPSR1PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 PPARG 2066/4885SERPINE1 101/4885STK39 1878/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.