SCHEMBL2269563

SCHEMBL2269563

O=C(Nc1cc(Oc2ccccc2)ccc1C(=O)O)c1ccccc1Cl

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
STK39 Q9UEW8 2/20 0.57
SERPINE1 P05121 1/20 0.55
CYP2C19 P33261 2/20 0.54
CYP1A2 P05177 1/20 0.54
HPGD P15428 1/20 0.54
ALDH1A1 P00352 1/20 0.53
HTT P42858 1/20 0.53
TDP1 Q9NUW8 1/20 0.53
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
PNLIP P16233 1/20 0.51
MAPK1 P28482 1/20 0.51
GFER P55789 1/20 0.51
PPARG P37231 1/20 0.51
PRSS12 P56730 1/20 0.49
PYGL P06737 1/20 0.49
CYP2C9 P11712 1/20 0.49
SLC16A3 O15427 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2270119 0.90 PPARG (0.64) STK39SERPINE1MEN1KMT2AL3MBTL1
SCHEMBL2275857 0.88 SERPINE1 (0.54) STK39SERPINE1CYP2C19MEN1KMT2A
SCHEMBL2274195 0.85 PNLIP (0.66) STK39HTTMEN1KMT2AL3MBTL1
SCHEMBL2268019 0.84 MAPK1 (0.57) CYP2C19HPGDALDH1A1HTTMEN1
SCHEMBL2275036 0.84 L3MBTL1 (0.64) SERPINE1CYP2C19HPGDTDP1MEN1
SCHEMBL2273564 0.84 HDAC1 (0.61) SERPINE1ALDH1A1HTTMEN1KMT2A
SCHEMBL2271588 0.83 SERPINE1 (0.64) SERPINE1TDP1MEN1KMT2APYGL
SCHEMBL2272800 0.83 HTT (0.52) SERPINE1HTTMEN1KMT2AL3MBTL1
SCHEMBL2272043 0.83 SERPINE1 (0.75) SERPINE1ALDH1A1HTTTDP1MEN1
SCHEMBL2275201 0.83 ACLY (0.67) STK39SERPINE1MEN1KMT2APRSS12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
CN-101094829-A Novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD (JP) 2007-12-26 CN disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 STK39 1878/4885SERPINE1 101/4885CYP2C19 1098/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.