SCHEMBL2273465

SCHEMBL2273465

CC(C)(C)OC(=O)c1ccc(Oc2ccccc2)cc1NC(=O)COc1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.56
MAPK10 P53779 2/20 0.56
ALDH1A1 P00352 2/20 0.56
HSD17B10 Q99714 1/20 0.56
L3MBTL1 Q9Y468 2/20 0.52
HCAR2 Q8TDS4 2/20 0.51
RAB9A P51151 4/20 0.50
NPC1 O15118 4/20 0.50
GAA P10253 2/20 0.49
GSK3B P49841 1/20 0.47
CYP1A2 P05177 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
KDM4E B2RXH2 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2270139 0.84 HCAR2 (0.62) TSHRMAPK10ALDH1A1HSD17B10L3MBTL1
SCHEMBL2276220 0.79 L3MBTL1 (0.55) ALDH1A1L3MBTL1RAB9ANPC1GAA
SCHEMBL2269667 0.79 F10 (0.53) ALDH1A1GAAKDM4E
SCHEMBL2271662 0.78 KMT2A (0.57) TSHRHSD17B10RAB9ANPC1GAA
SCHEMBL2270366 0.78 STK39 (0.47) ALDH1A1L3MBTL1
SCHEMBL2269139 0.77 CYP2C9 (0.47) ALDH1A1HSD17B10RAB9ANPC1CYP2C9
SCHEMBL2275596 0.77 FABP1 (0.51) ALDH1A1RAB9ANPC1
SCHEMBL2276375 0.76 GRIK1 (0.49) TSHRRAB9ANPC1CYP1A2CYP2C9
SCHEMBL2275426 0.76 GRM5 (0.46) RAB9ANPC1
SCHEMBL14428179 0.76 NPC1 (0.61) TSHRMAPK10ALDH1A1HSD17B10L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 TSHR 3951/4885MAPK10 181/4885ALDH1A1 645/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.