SCHEMBL2274270

SCHEMBL2274270

O=C(Nc1cc(Oc2ccccc2)ccc1C(=O)O)c1ccno1

nearest known ligand 0.54

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.54
MEN1 O00255 2/20 0.54
MAPK1 P28482 2/20 0.54
HDAC1 Q13547 1/20 0.51
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
SERPINE1 P05121 1/20 0.46
RXFP2 Q8WXD0 1/20 0.45
RXFP1 Q9HBX9 1/20 0.45
CSF1R P07333 1/20 0.45
KDM4C Q9H3R0 1/20 0.45
PYGL P06737 1/20 0.43
PYGM P11217 1/20 0.43
MAPT P10636 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
GFER P55789 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2272461 0.81 SMN1; SMN2 (0.55) KMT2AMEN1CYP2C9CYP2C19SERPINE1
SCHEMBL2270142 0.80 KMT2A (0.52) KMT2AMEN1MAPK1HDAC1RXFP2
SCHEMBL2271588 0.79 SERPINE1 (0.64) KMT2AMEN1SERPINE1PYGLPYGM
SCHEMBL2269197 0.78 TSHR (0.58) KMT2AMEN1HDAC1MAPTSMN1; SMN2
SCHEMBL2275036 0.78 L3MBTL1 (0.64) KMT2AMEN1MAPK1CYP2C9CYP2C19
SCHEMBL2273634 0.77 SERPINE1 (0.60) KMT2AMEN1SERPINE1PYGLPYGM
SCHEMBL2276447 0.77 SERPINE1 (0.54) CYP2C9CYP2C19SERPINE1PYGLPYGM
SCHEMBL2274965 0.77 L3MBTL1 (0.49) KMT2AMEN1MAPK1CYP2C9CYP2C19
SCHEMBL2273868 0.76 NPC1 (0.57) HDAC1SERPINE1KDM4CMAPTSMN1; SMN2
SCHEMBL2274195 0.76 PNLIP (0.66) KMT2AMEN1MAPK1MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 KMT2A 1669/4885MEN1 3105/4885MAPK1 168/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.