SCHEMBL2274595

SCHEMBL2274595

O=C(Nc1cc(Oc2ccccc2)ccc1C(=O)O)c1cccs1

nearest known ligand 0.70

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.70
TDP1 Q9NUW8 1/20 0.70
ATM Q13315 1/20 0.63
NPC1 O15118 2/20 0.53
RAB9A P51151 2/20 0.53
TSHR P16473 1/20 0.51
MEN1 O00255 3/20 0.49
KMT2A Q03164 3/20 0.49
MAPT P10636 1/20 0.49
HPGD P15428 1/20 0.49
HTT P42858 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
HDAC3 O15379 1/20 0.49
HDAC1 Q13547 1/20 0.49
APLNR P35414 1/20 0.49
POLB P06746 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2271588 0.81 SERPINE1 (0.64) TDP1NPC1RAB9AMEN1KMT2A
SCHEMBL2269832 0.81 HDAC3 (0.74) LMNATDP1ATMNPC1RAB9A
SCHEMBL15434968 0.80 LMNA (0.74) LMNATDP1ATMNPC1RAB9A
SCHEMBL2276877 0.80 HDAC1 (0.52) LMNATDP1MEN1KMT2AL3MBTL1
SCHEMBL38652227 0.80 RAB9A (0.74) LMNATDP1ATMNPC1RAB9A
SCHEMBL13701150 0.80 RAB9A (0.74) LMNATDP1ATMNPC1RAB9A
SCHEMBL1307641 0.79 KCNMA1 (0.71) LMNANPC1RAB9AMEN1KMT2A
SCHEMBL1307665 0.79 NPC1 (0.58) LMNATDP1NPC1RAB9ATSHR
SCHEMBL2276272 0.79 MEN1 (0.58) LMNAMEN1KMT2AL3MBTL1
SCHEMBL2275857 0.79 SERPINE1 (0.54) MEN1KMT2AHDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 LMNA 3235/4885TDP1 3823/4885ATM 2986/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.