SCHEMBL2276272

SCHEMBL2276272

O=C(O)c1ccc(Oc2ccccc2)cc1NC(=O)c1ccccc1C(F)(F)F

nearest known ligand 0.58

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.58
KMT2A Q03164 2/20 0.58
GRIK1 P39086 1/20 0.49
KCNK3 O14649 1/20 0.49
KCNK9 Q9NPC2 1/20 0.49
RXFP1 Q9HBX9 2/20 0.48
MAPK1 P28482 1/20 0.48
GFER P55789 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
LMNA P02545 1/20 0.47
GAA P10253 1/20 0.47
PYGL P06737 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
SERPINE1 P05121 1/20 0.46
PTGS1 P23219 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2274737 0.90 AVPR2 (0.49) MEN1KMT2AGRIK1RXFP1PYGL
SCHEMBL2275036 0.84 L3MBTL1 (0.64) MEN1KMT2AMAPK1GFERL3MBTL1
SCHEMBL2275706 0.83 SERPINE1 (0.58) KMT2APYGLSERPINE1
SCHEMBL2274195 0.82 PNLIP (0.66) MEN1KMT2AMAPK1GFERL3MBTL1
SCHEMBL2269112 0.82 ACLY (0.59) RXFP1PYGLCYP2C9CYP2C19SERPINE1
SCHEMBL2272432 0.81 PYGL (0.55) MEN1KMT2AGRIK1PYGLSERPINE1
SCHEMBL2268019 0.81 MAPK1 (0.57) MEN1KMT2AMAPK1GFERL3MBTL1
SCHEMBL2274690 0.81 ACLY (0.61) MEN1KMT2AGRIK1KCNK3KCNK9
SCHEMBL2269563 0.81 STK39 (0.57) MEN1KMT2AMAPK1GFERL3MBTL1
SCHEMBL2271588 0.80 SERPINE1 (0.64) MEN1KMT2AGRIK1PYGLSERPINE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101094829-B novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO.,LTD. (JP) 2012-02-08 CN disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 MEN1 3105/4885KMT2A 1669/4885GRIK1 2029/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.