SCHEMBL2275549

SCHEMBL2275549

CC(C)(C)OC(=O)c1ccc(CCc2ccccc2)cc1NC(=O)c1c(Cl)cccc1Cl

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC16A3 O15427 1/20 0.43
P2RX7 Q99572 1/20 0.42
ITGB1 P05556 8/20 0.41
ITGA4 P13612 8/20 0.41
KDM4E B2RXH2 2/20 0.41
ALDH1A1 P00352 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
HPGD P15428 1/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
POLB P06746 1/20 0.41
PLK1 P53350 1/20 0.41
PTGES O14684 1/20 0.39
ALOX15 P16050 1/20 0.39
SCN5A Q14524 1/20 0.38
SCN2A Q99250 1/20 0.38
LMNA P02545 1/20 0.38
MAPT P10636 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2272564 0.85 ACLY (0.48) ALDH1A1HPGDMEN1KMT2ALMNA
SCHEMBL4222218 0.85 P2RX7 (0.46) P2RX7MEN1KMT2ALMNA
SCHEMBL2269795 0.84 SLC16A3 (0.55) SLC16A3ITGB1ITGA4NPC1RAB9A
SCHEMBL2277921 0.84 ACLY (0.49) SMN1; SMN2NPC1RAB9AHPGDMEN1
SCHEMBL2270366 0.82 STK39 (0.47) ALDH1A1MEN1KMT2APOLB
SCHEMBL2275189 0.82 MAPK1 (0.54) KDM4EALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL2271237 0.81 PLK1 (0.48) SLC16A3KDM4EPLK1
SCHEMBL2274675 0.81 PLK1 (0.46) KDM4ENPC1RAB9AMEN1KMT2A
SCHEMBL2269130 0.79 PTGS2 (0.44) KDM4EALDH1A1NPC1HPGDMEN1
SCHEMBL4222764 0.79 AKR1C3 (0.49) P2RX7KDM4EALDH1A1SMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 SLC16A3 380/4885P2RX7 3043/4885ITGB1 2388/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.