SCHEMBL2277696

SCHEMBL2277696

O=C(Nc1cc(Oc2cccc(C(F)(F)F)c2)ccc1C(=O)O)c1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MPO P05164 1/20 0.59
GAA P10253 1/20 0.57
PYGL P06737 2/20 0.56
RXFP1 Q9HBX9 2/20 0.55
GRIK1 P39086 1/20 0.54
AKR1C3 P42330 1/20 0.53
AKR1C2 P52895 1/20 0.53
MAPK14 Q16539 1/20 0.53
KCNK3 O14649 1/20 0.52
HPSE Q9Y251 1/20 0.52
PYGM P11217 1/20 0.52
KCNK2 O95069 1/20 0.52
KCNK10 P57789 1/20 0.52
LMNA P02545 1/20 0.51
ALDH1A1 P00352 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2272613 0.94 LMNA (0.56) MPOGAAPYGLRXFP1AKR1C3
SCHEMBL2272432 0.92 PYGL (0.55) MPOPYGLGRIK1MAPK14PYGM
SCHEMBL2275706 0.91 SERPINE1 (0.58) MPOPYGLMAPK14HPSEPYGM
SCHEMBL2269112 0.87 ACLY (0.59) PYGLRXFP1HPSEPYGMKCNK2
SCHEMBL2271588 0.86 SERPINE1 (0.64) PYGLGRIK1HPSEPYGM
SCHEMBL2269841 0.86 IGF2BP2 (0.61) PYGLGRIK1MAPK14HPSEPYGM
SCHEMBL2274737 0.85 AVPR2 (0.49) PYGLRXFP1GRIK1AKR1C3AKR1C2
SCHEMBL2269555 0.84 HPSE (0.55) PYGLGRIK1HPSEPYGM
SCHEMBL2274009 0.83 IGF2BP2 (0.61) PYGLGRIK1MAPK14HPSEPYGM
SCHEMBL2271920 0.83 SERPINE1 (0.57) PYGLGRIK1AKR1C3AKR1C2HPSE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101094829-B novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO.,LTD. (JP) 2012-02-08 CN disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 MPO 66/4885GAA 2590/4885PYGL 1834/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.