Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 4/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 2/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | APOB | P04114 | 1/20 | 0.34 |
| ▸ | MTTP | P55157 | 1/20 | 0.34 |
| ▸ | FPR1 | P21462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2279512 | 0.84 | MCHR1 (0.39) | DGAT1MCHR1OPRD1TRPV1TDP2 | |
| SCHEMBL2280666 | 0.79 | DGAT1 (0.39) | DGAT1MCHR1OPRD1TDP2BRD4 | |
| SCHEMBL2196468 | 0.78 | MCHR1 (0.39) | DGAT1MCHR1TDP2BRD4CREBBP | |
| SCHEMBL2196467 | 0.78 | MCHR1 (0.39) | DGAT1MCHR1TDP2BRD4CREBBP | |
| SCHEMBL2197280 | 0.77 | DGAT1 (0.41) | DGAT1MCHR1BRD4CREBBPFPR2 | |
| SCHEMBL2198162 | 0.77 | TDP2 (0.42) | DGAT1TDP2APPBRD4CREBBP | |
| SCHEMBL2279505 | 0.76 | SCN1A (0.39) | MCHR1BRD4CREBBPAPOBMTTP | |
| SCHEMBL2198200 | 0.75 | MCHR1 (0.36) | MCHR1BRD4CREBBPFPR2APOB | |
| SCHEMBL2296052 | 0.72 | SDCBP (0.43) | DGAT1BRD4CREBBP | |
| SCHEMBL2356973 | 0.71 | DGAT1 (0.53) | DGAT1MCHR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |