Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | S100A4 | P26447 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30048865 | 1.00 | LMNA (0.51) | LMNATDP1ATMMEN1KMT2A | |
| SCHEMBL27575559 | 0.80 | KMT2A (0.55) | LMNATDP1ATMMEN1KMT2A | |
| SCHEMBL537408 | 0.79 | KDM4E (0.56) | LMNAMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL23121513 | 0.79 | ANPEP (0.44) | LMNAKMT2AMAPTALDH1A1CA12 | |
| SCHEMBL30225703 | 0.79 | KDM4E (0.56) | LMNAMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL5997917 | 0.77 | MAPT (0.49) | LMNATDP1ATMMEN1KMT2A | |
| SCHEMBL74973 | 0.76 | L3MBTL1 (0.55) | KMT2AMAPTALDH1A1CA12CA2 | |
| SCHEMBL31241181 | 0.76 | L3MBTL1 (0.55) | KMT2AMAPTALDH1A1CA12CA2 | |
| SCHEMBL4538988 | 0.75 | PTGS2 (0.39) | KMT2AMAPTALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL4375792 | 0.75 | CA1 (0.59) | LMNATDP1ATMKMT2AS100A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228475-A1 | PROCESSES FOR THE PREPARATION OF (S)-2-(2,6-DIOXOPIPERIDIN-3-YL)-4-((2-FLUORO-4-((3-MORPHOLINOAZETIDIN-1-YL)METHYL)BENZYL)AMINO)ISOINDOLINE-1,3-DIONE | CELGENE CORPORATION | 2024-07-11 | — | — | US | claimed |
| EP-4359380-A1 | PROCESSES FOR THE PREPARATION OF (S)-2-(2,6-DIOXOPIPERIDIN-3-YL)-4-((2-FLUORO-4-((3-MORPHOLINOAZETIDIN-1-YL) METHYL)BENZYL) AMINO)ISOINDOLINE-1,3-DIONE | Celgene Corporation (US) | 2024-05-01 | — | — | EP | claimed |
| CN-117425642-A | Preparation method of (S) -2- (2, 6-dioxopiperidine-3-yl) -4- ((2-fluoro-4- ((3-morpholinoazetidin-1-yl) methyl) benzyl) amino) isoindoline-1, 3-dione | 新基公司 | 2024-01-19 | — | — | CN | claimed |
| WO-2022271557-A1 | PROCESSES FOR THE PREPARATION OF (S)-2-(2,6-DIOXOPIPERIDIN-3-YL)-4-((2-FLUORO-4-((3-MORPHOLINOAZETIDIN-1-YL) METHYL)BENZYL) AMINO)ISOINDOLINE-1,3-DIONE | CELGENE CORPORATION (US) | 2022-12-29 | — | — | WO | claimed |
| US-9822093-B2 | Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds | CELGENE CORPORATION (US) | 2017-11-21 | — | — | US | claimed |
| US-20160297791-A1 | PROCESSES FOR THE PREPARATION OF 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE COMPOUNDS | CELGENE CORP (US) | 2016-10-13 | — | — | US | claimed |
| CN-102643267-B | The preparation method of 4-amino-2-(2,6-dioxopiperidin-3-base) isoindoline-1,3-dione compounds | CELGENE CORP. (US) | 2015-09-16 | — | — | CN | claimed |
| EP-2380887-B1 | Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds | CELGENE CORP (US) | 2013-08-07 | — | — | EP | claimed |
| CN-102643267-A | Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds | CELGENE CORP | 2012-08-22 | — | — | CN | claimed |
| EP-2380887-A1 | Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds | Celgene Corporation (US) | 2011-10-26 | — | — | EP | claimed |
| US-20110224440-A1 | PROCESSES FOR THE PREPARATION OF 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE COMPOUNDS | CELGENE CORPORATION | 2011-09-15 | — | — | US | claimed |
| CN-101253163-A | Process for preparing 4-amino-2- (2, 6-dioxopiperidin-3-yl) isoindoline-1, 3-dione compounds | CELGENE CORP (US) | 2008-08-27 | — | — | CN | claimed |
| EP-1907373-A1 | PROCESSES FOR THE PREPARATION OF 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE COMPOUNDS | CELGENE CORPORATION (US) | 2008-04-09 | — | — | EP | claimed |
| WO-2007005972-A1 | PROCESSES FOR THE PREPARATION OF 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE COMPOUNDS | CELGENE CORPORATION (US) | 2007-01-11 | — | — | WO | claimed |
| US-20070004920-A1 | Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds | CELGENE CORPORATION AN ORGNIZATION OF THE STATE NEW JERSEY (US) | 2007-01-04 | — | — | US | claimed |
| US-4224441-A | Derivatives of 7-aminocephalosporanic acid | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1980-09-23 | — | — | US | claimed |
| US-4166178-A | 3-ACYLOXYMETHYL-CEPHEM COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1979-08-28 | — | — | US | claimed |
| EP-4739668-A1 | 1,3-ISOINDOLINEDIONE DERIVATIVES AND HETEROAROMATIC ANALOGUES FOR STIMULATING ENDOTHELIAL CELL-PERICYTE INTERACTION | Academisch Ziekenhuis Leiden (h.o.d.n. LUMC) (NL) | 2026-05-13 | — | — | EP | disclosed |
| US-4224441-A | Derivatives of 7-aminocephalosporanic acid | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1980-09-23 | — | — | US | disclosed |
| US-4166178-A | 3-ACYLOXYMETHYL-CEPHEM COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1979-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224440-A1 | PROCESSES FOR THE PREPARATION OF 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE COMPOUNDS | TNF, TRAF2, IL1A | LMNA 1998/4885TDP1 1052/4885ATM 2317/4885 |
| US-20160297791-A1 | PROCESSES FOR THE PREPARATION OF 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE COMPOUNDS | TNF, TRAF2, IL1A | LMNA 1998/4885TDP1 1052/4885ATM 2317/4885 |
| US-20240228475-A1 | PROCESSES FOR THE PREPARATION OF (S)-2-(2,6-DIOXOPIPERIDIN-3-YL)-4-((2-FLUORO-4-((3-MORPHOLINOAZETIDIN-1-YL)METHYL)BENZYL)AMINO)ISOINDOLINE-1,3-DIONE | AQP1, AQP3, ADH1C | LMNA 1131/4885TDP1 836/4885ATM 3694/4885 |
| US-20070004920-A1 | Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds | TNF, DHPS, IL1A | LMNA 3041/4885TDP1 1784/4885ATM 3226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.