Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 5/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18636747 | 0.94 | GAA (0.43) | GAATHRATHRBTGM2ALDH1A1 | |
| SCHEMBL18630160 | 0.86 | THRA (0.46) | GAATHRATHRBTGM2ALDH1A1 | |
| SCHEMBL18630143 | 0.83 | TGM2 (0.46) | GAATHRATHRBTGM2ALDH1A1 | |
| SCHEMBL11795978 | 0.80 | TGM2 (0.50) | GAATHRATHRBTGM2ALDH1A1 | |
| SCHEMBL18630146 | 0.78 | TGM2 (0.42) | GAATGM2ALDH1A1TSHRMAPK1 | |
| SCHEMBL28511134 | 0.77 | TGM2 (0.49) | GAATGM2ALDH1A1BTKEGFR | |
| SCHEMBL11793243 | 0.76 | TGM2 (0.46) | GAATHRATHRBTGM2ALDH1A1 | |
| SCHEMBL4325063 | 0.74 | GAA (0.70) | GAATGM2ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL27978331 | 0.74 | TGM2 (0.46) | GAATGM2ALDH1A1BTKEGFR | |
| SCHEMBL11796052 | 0.74 | GAA (0.45) | GAATHRATHRBTGM2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11224557-B2 | Dental composition | DENTSPLY SIRONA INC (US) | 2022-01-18 | — | — | US | disclosed |
| US-20220000721-A1 | BIFUNCTIONAL AND POLYFUNCTIONAL COINITIATORS IN DENTAL COMPOSITIONS | DENTSPLY SIRONA INC. (US) | 2022-01-06 | — | — | US | disclosed |
| US-20200405585-A1 | DENTAL COMPOSITION | DENTSPLY SIRONA INC. (US) | 2020-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11224557-B2 | Dental composition | GPX4, GPX1, NOXO1 | GAA 3279/4885THRA 4027/4885THRB 4564/4885 |
| US-20220000721-A1 | BIFUNCTIONAL AND POLYFUNCTIONAL COINITIATORS IN DENTAL COMPOSITIONS | DUOX2, DUOX1, QSOX1 | GAA 2841/4885THRA 3004/4885THRB 3213/4885 |
| US-20200405585-A1 | DENTAL COMPOSITION | CBR3, CBR1, PRDX3 | GAA 2604/4885THRA 3979/4885THRB 4516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.