Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 2/20 | 0.37 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | CASP2 | P42575 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904369 | 0.76 | TDP2 (0.50) | LMNATDP1ALDH1A1SMN1; SMN2GRM5 | |
| SCHEMBL22909125 | 0.74 | SOD1 (0.40) | LMNAALDH1A1SMN1; SMN2CASP3KDM4E | |
| SCHEMBL26473527 | 0.74 | HDAC4 (0.41) | CASP3CASP7CASP2CASP6CASP8 | |
| SCHEMBL5506330 | 0.73 | MAOA (0.51) | LMNAALDH1A1SMN1; SMN2CASP3CASP7 | |
| SCHEMBL24701314 | 0.72 | LMNA (0.43) | LMNATDP1ALDH1A1SMN1; SMN2FFAR4 | |
| SCHEMBL22904576 | 0.71 | DAO (0.50) | LMNATDP1ALDH1A1SMN1; SMN2CASP3 | |
| SCHEMBL262473 | 0.70 | GSK3B (0.50) | TDP1ALDH1A1CASP3CASP7CASP2 | |
| SCHEMBL22904147 | 0.69 | MAOB (0.38) | LMNASMN1; SMN2CASP3CASP7CASP2 | |
| SCHEMBL22909253 | 0.69 | CASP3 (0.45) | LMNATDP1ALDH1A1SMN1; SMN2CASP3 | |
| SCHEMBL13839612 | 0.69 | KCNA3 (0.39) | LMNATDP1ALDH1A1SMN1; SMN2FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |