Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | CASP2 | P42575 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.38 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22909253 | 0.81 | CASP3 (0.45) | DAOCASP3CASP2CASP7CASP6 | |
| SCHEMBL27553346 | 0.80 | KDM4E (0.41) | DAOCASP3ALDH1A1MAPTGSK3B | |
| SCHEMBL262473 | 0.78 | GSK3B (0.50) | CASP3CASP2CASP7CASP6CASP8 | |
| SCHEMBL22904128 | 0.74 | TDP2 (0.51) | CASP3CASP7CASP6CASP8MAPT | |
| SCHEMBL22909125 | 0.72 | SOD1 (0.40) | CASP3MAOAMAOBLMNAALDH1A1 | |
| SCHEMBL26473527 | 0.72 | HDAC4 (0.41) | CASP3CASP2CASP7CASP6CASP8 | |
| SCHEMBL22904554 | 0.71 | LMNA (0.44) | CASP3CASP2CASP7CASP6CASP8 | |
| SCHEMBL5506330 | 0.71 | MAOA (0.51) | CASP3CASP2CASP7CASP6CASP8 | |
| SCHEMBL28756658 | 0.70 | MAPT (0.38) | DAOCASP3ALDH1A1MAPTGSK3B | |
| SCHEMBL26454576 | 0.70 | P2RX3 (0.36) | CASP3CASP2CASP7CASP6CASP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |